Compound Detail
CHEMBL395263
SAVININ Enter ChEMBL ID:
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Basic Information
| ChEMBL ID | CHEMBL395263 |
| Name | SAVININ |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | CMJGAYUQSLJSCR-ULIPXBITSA-N |
2
Targets
3
Activities
3
Assay Types
0
PK Parameters
6
Publications
0
Known Names
Molecular Properties
352.3
MW (Da)
2.94
ALogP
6
HBA
0
HBD
63.2
PSA (Ų)
0.63
QED
0
Ro5 Violations
3
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
EC50 1 meas. best 5.95
IC50 1 meas. best 4.6
Ki 1 meas. best 5.04
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| SARS-CoV CHEMBL4303836 | EC50 | 5.95 | 5.95 | 1130.0 | 1 |
| Replicase polyprotein 1a CHEMBL3927 | Ki | 5.04 | 5.04 | 9100.0 | 1 |
| Replicase polyprotein 1a CHEMBL3927 | IC50 | 4.6 | 4.6 | 25000.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| SARS-CoV | EC50 | = | 1130.0 | nM | 5.95 | Antiviral activity against SARS coronavirus in Vero E6 cells assessed as inhibit... | 17663539 |
| Replicase polyprotein 1a | Ki | = | 9100.0 | nM | 5.04 | Inhibition of SARS coronavirus 3CL protease | 17663539 |
| Replicase polyprotein 1a | IC50 | = | 25000.0 | nM | 4.6 | Inhibition of SARS coronavirus 3CL protease | 17663539 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 17663539 | 10.1021/jm070295s | SARS-CoV | 5 |
| 17663539 | 10.1021/jm070295s | Replicase polyprotein 1a | 2 |
| 17663539 | 10.1021/jm070295s | Vero | 1 |
| 17663539 | 10.1021/jm070295s | Unchecked | 1 |
| 6539809 | 10.1021/np50032a017 | Rattus norvegicus | 1 |
| - | 10.1021/np50015a016 | NON-PROTEIN TARGET | 1 |
Data from ChEMBL 36 via Core Engine