Assay Detail
Binding
CHEMBL894339
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Inhibition of human recombinant aurora C kinase
20
Total Activities
20
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Publication
An integrated computational approach to the phenomenon of potent and selective inhibition of aurora kinases B and C by a series of 7-substituted indirubins.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 20 | 6.01 | 6.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL409450 | 6BIO | — | 1 | 6.70 |
| CHEMBL126077 | INDIRUBIN-3-MONOXIME | — | 1 | 6.52 |
| CHEMBL211243 | — | — | 1 | 6.40 |
| CHEMBL209648 | — | — | 1 | 6.22 |
| CHEMBL209849 | — | — | 1 | 6.16 |
| CHEMBL373834 | — | — | 1 | 6.16 |
| CHEMBL213650 | — | — | 1 | 6.05 |
| CHEMBL243985 | — | — | 1 | 6.00 |
| CHEMBL212174 | — | — | 1 | 6.00 |
| CHEMBL395766 | — | — | 1 | 5.35 |
| CHEMBL395077 | — | — | 1 | 4.55 |
| CHEMBL397719 | — | — | 1 | - |
| CHEMBL243556 | — | — | 1 | - |
| CHEMBL214173 | — | — | 1 | - |
| CHEMBL243776 | — | — | 1 | - |
| CHEMBL378191 | — | — | 1 | - |
| CHEMBL397720 | — | — | 1 | - |
| CHEMBL210446 | — | — | 1 | - |
| CHEMBL244191 | — | — | 1 | - |
| CHEMBL379160 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL409450 | 6BIO | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL126077 | INDIRUBIN-3-MONOXIME | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL211243 | — | IC50 | = | 400.0 | nM | 6.40 |
| CHEMBL209648 | — | IC50 | = | 600.0 | nM | 6.22 |
| CHEMBL209849 | — | IC50 | = | 700.0 | nM | 6.16 |
| CHEMBL373834 | — | IC50 | = | 700.0 | nM | 6.16 |
| CHEMBL213650 | — | IC50 | = | 900.0 | nM | 6.05 |
| CHEMBL243985 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL212174 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL395766 | — | IC50 | = | 4500.0 | nM | 5.35 |
| CHEMBL395077 | — | IC50 | = | 28000.0 | nM | 4.55 |
| CHEMBL397719 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL243556 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL214173 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL243776 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL378191 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL397720 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL210446 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL244191 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL379160 | — | IC50 | > | 100000.0 | nM | - |