Assay Detail
Functional
CHEMBL894352
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Antiprion activity in ScN2a cells assessed as inhibition of protease-resistant prion protein accumulation
22
Total Activities
22
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mus musculus |
| Cell Type | ScN2a |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
New series of antiprion compounds: pyrazolone derivatives have the potent activity of inhibiting protease-resistant prion protein accumulation.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 15 | 7.08 | 9.30 |
| Activity | 7 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL373839 | — | — | 1 | 9.30 |
| CHEMBL387129 | — | — | 1 | 8.52 |
| CHEMBL373481 | — | — | 1 | 8.22 |
| CHEMBL223594 | — | — | 1 | 8.22 |
| CHEMBL220663 | — | — | 1 | 7.89 |
| CHEMBL223084 | — | — | 1 | 7.40 |
| CHEMBL244779 | — | — | 1 | 7.10 |
| CHEMBL375548 | — | — | 1 | 6.90 |
| CHEMBL219655 | — | — | 1 | 6.80 |
| CHEMBL223006 | — | — | 1 | 6.40 |
| CHEMBL387593 | — | — | 1 | 6.40 |
| CHEMBL244778 | — | — | 1 | 5.70 |
| CHEMBL1294 | QUINIDINE | 4.0 | 1 | 5.30 |
| CHEMBL170 | QUININE | 4.0 | 1 | 5.00 |
| CHEMBL219768 | — | — | 1 | - |
| CHEMBL223190 | — | — | 1 | - |
| CHEMBL373456 | — | — | 1 | - |
| CHEMBL222617 | — | — | 1 | - |
| CHEMBL223155 | — | — | 1 | - |
| CHEMBL219656 | — | — | 1 | - |
| CHEMBL376894 | — | — | 1 | - |
| CHEMBL290916 | EDARAVONE | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL373839 | — | IC50 | = | 0.5 | nM | 9.30 |
| CHEMBL387129 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL373481 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL223594 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL220663 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL223084 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL244779 | — | IC50 | = | 79.0 | nM | 7.10 |
| CHEMBL375548 | — | IC50 | = | 126.0 | nM | 6.90 |
| CHEMBL219655 | — | IC50 | = | 158.0 | nM | 6.80 |
| CHEMBL223006 | — | IC50 | = | 398.0 | nM | 6.40 |
| CHEMBL387593 | — | IC50 | = | 398.0 | nM | 6.40 |
| CHEMBL244778 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL1294 | QUINIDINE | IC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL170 | QUININE | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL219768 | — | Activity | - | — | - | |
| CHEMBL223190 | — | Activity | - | — | - | |
| CHEMBL373456 | — | Activity | - | — | - | |
| CHEMBL222617 | — | Activity | - | — | - | |
| CHEMBL223155 | — | Activity | - | — | - | |
| CHEMBL219656 | — | Activity | - | — | - | |
| CHEMBL376894 | — | Activity | - | — | - | |
| CHEMBL290916 | EDARAVONE | IC50 | > | 1000.0 | nM | - |