Assay Detail
Functional
CHEMBL894353
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Antiprion activity in F3 cells assessed as inhibition of protease-resistant prion protein accumulation
20
Total Activities
20
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mus musculus |
| Cell Type | N2a #58 F3 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
New series of antiprion compounds: pyrazolone derivatives have the potent activity of inhibiting protease-resistant prion protein accumulation.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 12 | 6.85 | 9.00 |
| Activity | 8 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL223084 | — | — | 1 | 9.00 |
| CHEMBL387129 | — | — | 1 | 8.52 |
| CHEMBL223190 | — | — | 1 | 7.80 |
| CHEMBL220663 | — | — | 1 | 7.60 |
| CHEMBL375548 | — | — | 1 | 6.80 |
| CHEMBL223594 | — | — | 1 | 6.30 |
| CHEMBL244779 | — | — | 1 | 6.20 |
| CHEMBL223006 | — | — | 1 | 6.20 |
| CHEMBL219655 | — | — | 1 | 6.10 |
| CHEMBL373481 | — | — | 1 | 6.00 |
| CHEMBL244778 | — | — | 1 | 5.90 |
| CHEMBL387593 | — | — | 1 | 5.80 |
| CHEMBL219768 | — | — | 1 | - |
| CHEMBL290916 | EDARAVONE | 4.0 | 1 | - |
| CHEMBL373456 | — | — | 1 | - |
| CHEMBL222617 | — | — | 1 | - |
| CHEMBL223155 | — | — | 1 | - |
| CHEMBL219656 | — | — | 1 | - |
| CHEMBL376894 | — | — | 1 | - |
| CHEMBL373839 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL223084 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL387129 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL223190 | — | IC50 | = | 16.0 | nM | 7.80 |
| CHEMBL220663 | — | IC50 | = | 25.0 | nM | 7.60 |
| CHEMBL375548 | — | IC50 | = | 158.0 | nM | 6.80 |
| CHEMBL223594 | — | IC50 | = | 501.0 | nM | 6.30 |
| CHEMBL244779 | — | IC50 | = | 631.0 | nM | 6.20 |
| CHEMBL223006 | — | IC50 | = | 631.0 | nM | 6.20 |
| CHEMBL219655 | — | IC50 | = | 794.0 | nM | 6.10 |
| CHEMBL373481 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL244778 | — | IC50 | = | 1260.0 | nM | 5.90 |
| CHEMBL387593 | — | IC50 | = | 1580.0 | nM | 5.80 |
| CHEMBL219768 | — | Activity | - | — | - | |
| CHEMBL290916 | EDARAVONE | Activity | - | — | - | |
| CHEMBL373456 | — | Activity | - | — | - | |
| CHEMBL222617 | — | Activity | - | — | - | |
| CHEMBL223155 | — | Activity | - | — | - | |
| CHEMBL219656 | — | Activity | - | — | - | |
| CHEMBL376894 | — | Activity | - | — | - | |
| CHEMBL373839 | — | Activity | - | — | - |