Assay Detail
Binding
CHEMBL894369
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Inhibition of Escherichia coli SHV1
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Escherichia coli |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
4-Substituted trinems as broad spectrum beta-lactamase inhibitors: structure-based design, synthesis, and biological activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 10 | 6.75 | 7.55 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL777 | CLAVULANIC ACID | 4.0 | 1 | 7.55 |
| CHEMBL395017 | — | — | 1 | 6.83 |
| CHEMBL396509 | — | — | 1 | 6.82 |
| CHEMBL397438 | — | — | 1 | 6.82 |
| CHEMBL230332 | — | — | 1 | 6.69 |
| CHEMBL396998 | — | — | 1 | 6.66 |
| CHEMBL404 | TAZOBACTAM | 4.0 | 1 | 6.65 |
| CHEMBL230859 | — | — | 1 | 6.55 |
| CHEMBL396753 | — | — | 1 | 6.47 |
| CHEMBL230226 | — | — | 1 | 6.42 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL777 | CLAVULANIC ACID | IC50 | = | 28.0 | nM | 7.55 |
| CHEMBL395017 | — | IC50 | = | 148.0 | nM | 6.83 |
| CHEMBL396509 | — | IC50 | = | 151.0 | nM | 6.82 |
| CHEMBL397438 | — | IC50 | = | 152.0 | nM | 6.82 |
| CHEMBL230332 | — | IC50 | = | 206.0 | nM | 6.69 |
| CHEMBL396998 | — | IC50 | = | 219.0 | nM | 6.66 |
| CHEMBL404 | TAZOBACTAM | IC50 | = | 222.0 | nM | 6.65 |
| CHEMBL230859 | — | IC50 | = | 284.0 | nM | 6.55 |
| CHEMBL396753 | — | IC50 | = | 340.0 | nM | 6.47 |
| CHEMBL230226 | — | IC50 | = | 385.0 | nM | 6.42 |