Assay Detail
Binding
CHEMBL894370
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Inhibition of Enterobacter cloacae AmpC
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Enterobacter cloacae |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Publication
4-Substituted trinems as broad spectrum beta-lactamase inhibitors: structure-based design, synthesis, and biological activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 10 | 6.42 | 7.21 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL396509 | — | — | 1 | 7.21 |
| CHEMBL397438 | — | — | 1 | 6.68 |
| CHEMBL230226 | — | — | 1 | 6.64 |
| CHEMBL230859 | — | — | 1 | 6.53 |
| CHEMBL396753 | — | — | 1 | 6.47 |
| CHEMBL396998 | — | — | 1 | 6.37 |
| CHEMBL230332 | — | — | 1 | 6.14 |
| CHEMBL395017 | — | — | 1 | 5.99 |
| CHEMBL404 | TAZOBACTAM | 4.0 | 1 | 5.74 |
| CHEMBL777 | CLAVULANIC ACID | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL396509 | — | IC50 | = | 62.0 | nM | 7.21 |
| CHEMBL397438 | — | IC50 | = | 209.0 | nM | 6.68 |
| CHEMBL230226 | — | IC50 | = | 229.0 | nM | 6.64 |
| CHEMBL230859 | — | IC50 | = | 295.0 | nM | 6.53 |
| CHEMBL396753 | — | IC50 | = | 341.0 | nM | 6.47 |
| CHEMBL396998 | — | IC50 | = | 430.0 | nM | 6.37 |
| CHEMBL230332 | — | IC50 | = | 720.0 | nM | 6.14 |
| CHEMBL395017 | — | IC50 | = | 1020.0 | nM | 5.99 |
| CHEMBL404 | TAZOBACTAM | IC50 | = | 1808.0 | nM | 5.74 |
| CHEMBL777 | CLAVULANIC ACID | IC50 | = | 136200.0 | nM | - |