Assay Detail
Binding
CHEMBL894371
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Inhibition of Escherichia coli TEM1
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Escherichia coli |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Publication
4-Substituted trinems as broad spectrum beta-lactamase inhibitors: structure-based design, synthesis, and biological activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 10 | 7.57 | 7.92 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL396998 | — | — | 1 | 7.92 |
| CHEMBL404 | TAZOBACTAM | 4.0 | 1 | 7.77 |
| CHEMBL397438 | — | — | 1 | 7.75 |
| CHEMBL395017 | — | — | 1 | 7.68 |
| CHEMBL230859 | — | — | 1 | 7.66 |
| CHEMBL777 | CLAVULANIC ACID | 4.0 | 1 | 7.52 |
| CHEMBL230332 | — | — | 1 | 7.50 |
| CHEMBL396753 | — | — | 1 | 7.41 |
| CHEMBL396509 | — | — | 1 | 7.26 |
| CHEMBL230226 | — | — | 1 | 7.24 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL396998 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL404 | TAZOBACTAM | IC50 | = | 17.0 | nM | 7.77 |
| CHEMBL397438 | — | IC50 | = | 18.0 | nM | 7.75 |
| CHEMBL395017 | — | IC50 | = | 21.0 | nM | 7.68 |
| CHEMBL230859 | — | IC50 | = | 22.0 | nM | 7.66 |
| CHEMBL777 | CLAVULANIC ACID | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL230332 | — | IC50 | = | 32.0 | nM | 7.50 |
| CHEMBL396753 | — | IC50 | = | 39.0 | nM | 7.41 |
| CHEMBL396509 | — | IC50 | = | 55.0 | nM | 7.26 |
| CHEMBL230226 | — | IC50 | = | 57.0 | nM | 7.24 |