Assay Detail
Functional
CHEMBL894953
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiviral activity against HCMV Davis in HEL cells assessed as reduction of virus plaque formation after 7 days
22
Total Activities
22
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Human betaherpesvirus 5 |
| Cell Type | HEL |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Synthesis and antiviral evaluation of 6-(alkyl-heteroaryl)furo[2,3-d]pyrimidin-2(3H)-one nucleosides and analogues with ethynyl, ethenyl, and ethyl spacers at C6 of the furopyrimidine core.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 22 | 4.87 | 5.08 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL243987 | — | — | 1 | 5.08 |
| CHEMBL182 | GANCICLOVIR | 4.0 | 1 | 5.06 |
| CHEMBL388713 | — | — | 1 | 5.06 |
| CHEMBL439574 | — | — | 1 | 4.96 |
| CHEMBL144817 | — | — | 1 | 4.19 |
| CHEMBL31634 | BRIVUDINE | 2.0 | 1 | - |
| CHEMBL396223 | — | — | 1 | - |
| CHEMBL245043 | — | — | 1 | - |
| CHEMBL244826 | — | — | 1 | - |
| CHEMBL244825 | — | — | 1 | - |
| CHEMBL397671 | — | — | 1 | - |
| CHEMBL244824 | — | — | 1 | - |
| CHEMBL244615 | — | — | 1 | - |
| CHEMBL244614 | — | — | 1 | - |
| CHEMBL244410 | — | — | 1 | - |
| CHEMBL244408 | — | — | 1 | - |
| CHEMBL244196 | — | — | 1 | - |
| CHEMBL244194 | — | — | 1 | - |
| CHEMBL243988 | — | — | 1 | - |
| CHEMBL344738 | CF1743 | — | 1 | - |
| CHEMBL184 | ACYCLOVIR | 4.0 | 1 | - |
| CHEMBL244409 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL243987 | — | EC50 | = | 8400.0 | nM | 5.08 |
| CHEMBL182 | GANCICLOVIR | EC50 | = | 8700.0 | nM | 5.06 |
| CHEMBL388713 | — | EC50 | = | 8700.0 | nM | 5.06 |
| CHEMBL439574 | — | EC50 | = | 11000.0 | nM | 4.96 |
| CHEMBL144817 | — | EC50 | = | 64000.0 | nM | 4.19 |
| CHEMBL31634 | BRIVUDINE | EC50 | - | — | - | |
| CHEMBL396223 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL245043 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL244826 | — | EC50 | > | 20000.0 | nM | - |
| CHEMBL244825 | — | EC50 | > | 20000.0 | nM | - |
| CHEMBL397671 | — | EC50 | > | 20000.0 | nM | - |
| CHEMBL244824 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL244615 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL244614 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL244410 | — | EC50 | > | 120000.0 | nM | - |
| CHEMBL244408 | — | EC50 | > | 540000.0 | nM | - |
| CHEMBL244196 | — | EC50 | > | 560000.0 | nM | - |
| CHEMBL244194 | — | EC50 | > | 130000.0 | nM | - |
| CHEMBL243988 | — | EC50 | > | 140000.0 | nM | - |
| CHEMBL344738 | CF1743 | EC50 | > | 10000.0 | nM | - |
| CHEMBL184 | ACYCLOVIR | EC50 | - | — | - | |
| CHEMBL244409 | — | EC50 | > | 130000.0 | nM | - |