Assay Detail
Functional
CHEMBL894957
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Cytotoxicity against human Hep3B cells after 72 hrs by MTT colorimetric method
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | Hep 3B2 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
First total synthesis of protoapigenone and its analogues as potent cytotoxic agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 13 | 5.89 | 6.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL244593 | — | — | 1 | 6.52 |
| CHEMBL397013 | — | — | 1 | 6.22 |
| CHEMBL53463 | DOXORUBICIN | 4.0 | 1 | 6.21 |
| CHEMBL244176 | — | — | 1 | 6.17 |
| CHEMBL245015 | — | — | 1 | 6.17 |
| CHEMBL244803 | — | — | 1 | 5.96 |
| CHEMBL245016 | — | — | 1 | 5.90 |
| CHEMBL245238 | — | — | 1 | 5.89 |
| CHEMBL414890 | PROTOAPIGENONE | — | 1 | 5.64 |
| CHEMBL245239 | — | — | 1 | 5.63 |
| CHEMBL397277 | — | — | 1 | 5.62 |
| CHEMBL394770 | — | — | 1 | 5.42 |
| CHEMBL396471 | — | — | 1 | 5.27 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL244593 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL397013 | — | IC50 | = | 600.0 | nM | 6.22 |
| CHEMBL53463 | DOXORUBICIN | IC50 | = | 620.0 | nM | 6.21 |
| CHEMBL244176 | — | IC50 | = | 670.0 | nM | 6.17 |
| CHEMBL245015 | — | IC50 | = | 670.0 | nM | 6.17 |
| CHEMBL244803 | — | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL245016 | — | IC50 | = | 1260.0 | nM | 5.90 |
| CHEMBL245238 | — | IC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL414890 | PROTOAPIGENONE | IC50 | = | 2270.0 | nM | 5.64 |
| CHEMBL245239 | — | IC50 | = | 2320.0 | nM | 5.63 |
| CHEMBL397277 | — | IC50 | = | 2390.0 | nM | 5.62 |
| CHEMBL394770 | — | IC50 | = | 3780.0 | nM | 5.42 |
| CHEMBL396471 | — | IC50 | = | 5410.0 | nM | 5.27 |