Assay Detail
Functional
CHEMBL895080
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Agonistic potency at human adrenergic alpha-2A receptor expressed in CHO cells assessed as forskolin-induced cAMP accumulation
8
Total Activities
8
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | CHO |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Alpha2-adrenoreceptors profile modulation. 3.1 (R)-(+)-m-nitrobiphenyline, a new efficient and alpha2C-subtype selective agonist.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 6 | 6.42 | 7.13 |
| Activity | 2 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL396013 | — | — | 1 | 7.13 |
| CHEMBL223836 | — | — | 1 | 6.98 |
| CHEMBL128168 | BIPHENYLINE | — | 1 | 6.94 |
| CHEMBL373535 | — | — | 1 | 6.50 |
| CHEMBL1437 | NOREPINEPHRINE | 4.0 | 1 | 6.43 |
| CHEMBL242265 | — | — | 1 | 4.54 |
| CHEMBL222928 | — | — | 1 | - |
| CHEMBL374584 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL396013 | — | EC50 | = | 74.13 | nM | 7.13 |
| CHEMBL223836 | — | EC50 | = | 104.71 | nM | 6.98 |
| CHEMBL128168 | BIPHENYLINE | EC50 | = | 114.82 | nM | 6.94 |
| CHEMBL373535 | — | EC50 | = | 316.23 | nM | 6.50 |
| CHEMBL1437 | NOREPINEPHRINE | EC50 | = | 371.54 | nM | 6.43 |
| CHEMBL242265 | — | EC50 | = | 28840.32 | nM | 4.54 |
| CHEMBL222928 | — | Activity | - | — | - | |
| CHEMBL374584 | — | Activity | - | — | - |