Assay Detail
Binding
CHEMBL895094
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Displacement of [3H]CP-55940 human CB2 receptor expressed in CHOK1 cells
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | CHO-K1 |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Naphthalen-1-yl-(4-pentyloxynaphthalen-1-yl)methanone: a potent, orally bioavailable human CB1/CB2 dual agonist with antihyperalgesic properties and restricted central nervous system penetration.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 6.87 | 8.89 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL559612 | CP-55940 | — | 1 | 8.89 |
| CHEMBL188 | WIN-552122 | — | 1 | 8.05 |
| CHEMBL244402 | — | — | 1 | 7.07 |
| CHEMBL243334 | — | — | 1 | 7.05 |
| CHEMBL244403 | — | — | 1 | 7.01 |
| CHEMBL390675 | — | — | 1 | 6.92 |
| CHEMBL244606 | — | — | 1 | 6.18 |
| CHEMBL244607 | — | — | 1 | 5.70 |
| CHEMBL244189 | — | — | 1 | 4.96 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL559612 | CP-55940 | IC50 | = | 1.3 | nM | 8.89 |
| CHEMBL188 | WIN-552122 | IC50 | = | 8.9 | nM | 8.05 |
| CHEMBL244402 | — | IC50 | = | 85.0 | nM | 7.07 |
| CHEMBL243334 | — | IC50 | = | 90.0 | nM | 7.05 |
| CHEMBL244403 | — | IC50 | = | 98.0 | nM | 7.01 |
| CHEMBL390675 | — | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL244606 | — | IC50 | = | 660.0 | nM | 6.18 |
| CHEMBL244607 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL244189 | — | IC50 | = | 11000.0 | nM | 4.96 |