Assay Detail
Functional
CHEMBL895097
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Agonist activity at human CB2 receptor expressed in CHOK1 cells assessed as reversal of forskolin-evoked cAMP accumulation
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | CHO-K1 |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Naphthalen-1-yl-(4-pentyloxynaphthalen-1-yl)methanone: a potent, orally bioavailable human CB1/CB2 dual agonist with antihyperalgesic properties and restricted central nervous system penetration.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 9 | 8.78 | 9.46 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL559612 | CP-55940 | — | 1 | 9.46 |
| CHEMBL188 | WIN-552122 | — | 1 | 9.33 |
| CHEMBL244403 | — | — | 1 | 7.55 |
| CHEMBL390675 | — | — | 1 | - |
| CHEMBL244607 | — | — | 1 | - |
| CHEMBL244606 | — | — | 1 | - |
| CHEMBL244402 | — | — | 1 | - |
| CHEMBL243334 | — | — | 1 | - |
| CHEMBL244189 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL559612 | CP-55940 | EC50 | = | 0.35 | nM | 9.46 |
| CHEMBL188 | WIN-552122 | EC50 | = | 0.47 | nM | 9.33 |
| CHEMBL244403 | — | EC50 | = | 27.9 | nM | 7.55 |
| CHEMBL390675 | — | EC50 | - | — | - | |
| CHEMBL244607 | — | EC50 | - | — | - | |
| CHEMBL244606 | — | EC50 | - | — | - | |
| CHEMBL244402 | — | EC50 | - | — | - | |
| CHEMBL243334 | — | EC50 | - | — | - | |
| CHEMBL244189 | — | EC50 | - | — | - |