Assay Detail
Functional
CHEMBL895122
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Antiproliferative activity against human HT29 cells after 4 hrs by microculture tetrazolium assay
15
Total Activities
15
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HT-29 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Synthesis and biological activities of new checkpoint kinase 1 inhibitors structurally related to granulatimide.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 15 | 4.79 | 5.42 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL244141 | — | — | 1 | 5.42 |
| CHEMBL244140 | — | — | 1 | 5.25 |
| CHEMBL240747 | GRANULATIMIDE | — | 1 | 5.24 |
| CHEMBL244142 | — | — | 1 | 5.14 |
| CHEMBL388648 | BIS-IMIDE A | — | 1 | 5.01 |
| CHEMBL413188 | ISOGRANULATIMIDE | — | 1 | 4.86 |
| CHEMBL230868 | — | — | 1 | 4.81 |
| CHEMBL395016 | — | — | 1 | 4.79 |
| CHEMBL243930 | — | — | 1 | 4.76 |
| CHEMBL388037 | — | — | 1 | 4.69 |
| CHEMBL397022 | — | — | 1 | 4.58 |
| CHEMBL244353 | — | — | 1 | 4.34 |
| CHEMBL388434 | — | — | 1 | 4.33 |
| CHEMBL394608 | — | — | 1 | 4.30 |
| CHEMBL243931 | — | — | 1 | 4.30 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL244141 | — | IC50 | = | 3800.0 | nM | 5.42 |
| CHEMBL244140 | — | IC50 | = | 5600.0 | nM | 5.25 |
| CHEMBL240747 | GRANULATIMIDE | IC50 | = | 5700.0 | nM | 5.24 |
| CHEMBL244142 | — | IC50 | = | 7280.0 | nM | 5.14 |
| CHEMBL388648 | BIS-IMIDE A | IC50 | = | 9700.0 | nM | 5.01 |
| CHEMBL413188 | ISOGRANULATIMIDE | IC50 | = | 13700.0 | nM | 4.86 |
| CHEMBL230868 | — | IC50 | = | 15500.0 | nM | 4.81 |
| CHEMBL395016 | — | IC50 | = | 16100.0 | nM | 4.79 |
| CHEMBL243930 | — | IC50 | = | 17400.0 | nM | 4.76 |
| CHEMBL388037 | — | IC50 | = | 20600.0 | nM | 4.69 |
| CHEMBL397022 | — | IC50 | = | 26400.0 | nM | 4.58 |
| CHEMBL244353 | — | IC50 | = | 46000.0 | nM | 4.34 |
| CHEMBL388434 | — | IC50 | = | 46400.0 | nM | 4.33 |
| CHEMBL394608 | — | IC50 | = | 50000.0 | nM | 4.30 |
| CHEMBL243931 | — | IC50 | = | 50600.0 | nM | 4.30 |