Compound Detail
CHEMBL243931
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Basic Information
| ChEMBL ID | CHEMBL243931 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | DCKZKNXQWSTPNW-UHFFFAOYSA-N |
4
Targets
4
Activities
1
Assay Types
0
PK Parameters
19
Publications
0
Known Names
Molecular Properties
332.3
MW (Da)
0.98
ALogP
5
HBA
3
HBD
120.1
PSA (Ų)
0.39
QED
0
Ro5 Violations
0
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 4 meas. best 7.57
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Serine/threonine-protein kinase Chk1 CHEMBL4630 | IC50 | 7.57 | 7.57 | 27.0 | 1 |
| L1210 CHEMBL386 | IC50 | 5.08 | 5.08 | 8400.0 | 1 |
| HCT-116 CHEMBL394 | IC50 | 4.81 | 4.81 | 15400.0 | 1 |
| HT-29 CHEMBL384 | IC50 | 4.3 | 4.3 | 50600.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Serine/threonine-protein kinase Chk1 | IC50 | = | 27.0 | nM | 7.57 | Inhibition of human Chk1 expressed in Sf9 cells | 17722905 |
| L1210 | IC50 | = | 8400.0 | nM | 5.08 | Antiproliferative activity against mouse L1210 cells after 4 hrs by microculture... | 17722905 |
| HCT-116 | IC50 | = | 15400.0 | nM | 4.81 | Antiproliferative activity against human HCT116 cells after 4 hrs by microcultur... | 17722905 |
| HT-29 | IC50 | = | 50600.0 | nM | 4.3 | Antiproliferative activity against human HT29 cells after 4 hrs by microculture ... | 17722905 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 17722905 | 10.1021/jm070664k | Unchecked | 5 |
| 17722905 | 10.1021/jm070664k | Serine/threonine-protein kinase Chk1 | 3 |
| 17722905 | 10.1021/jm070664k | RAF proto-oncogene serine/threonine-protein kinase | 1 |
| 17722905 | 10.1021/jm070664k | Protein kinase C alpha type | 1 |
| 17722905 | 10.1021/jm070664k | RAC-alpha serine/threonine-protein kinase | 1 |
| 17722905 | 10.1021/jm070664k | Ribosomal protein S6 kinase beta-1 | 1 |
| 17722905 | 10.1021/jm070664k | Dual specificity mitogen-activated protein kinase kinase 1 | 1 |
| 17722905 | 10.1021/jm070664k | MAP kinase-activated protein kinase 2 | 1 |
| 17722905 | 10.1021/jm070664k | Mitogen-activated protein kinase 1 | 1 |
| 17722905 | 10.1021/jm070664k | Glycogen synthase kinase-3 beta | 1 |
| 17722905 | 10.1021/jm070664k | Glycogen synthase kinase-3 alpha | 1 |
| 17722905 | 10.1021/jm070664k | Casein kinase I isoform delta | 1 |
| 17722905 | 10.1021/jm070664k | Casein kinase II subunit alpha | 1 |
| 17722905 | 10.1021/jm070664k | CDK9/cyclin T1 | 1 |
| 17722905 | 10.1021/jm070664k | Cyclin-dependent kinase 5/CDK5 activator 1 | 1 |
| 17722905 | 10.1021/jm070664k | Proto-oncogene tyrosine-protein kinase Src | 1 |
| 17722905 | 10.1021/jm070664k | L1210 | 1 |
| 17722905 | 10.1021/jm070664k | HCT-116 | 1 |
| 17722905 | 10.1021/jm070664k | HT-29 | 1 |
Data from ChEMBL 36 via Core Engine