Assay Detail
Binding
CHEMBL895144
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H]quisqualate from mGluR1 receptor expressed in BHK cells
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | BHK |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Publication
Synthesis, molecular modeling studies, and preliminary pharmacological characterization of all possible 2-(2'-sulfonocyclopropyl)glycine stereoisomers as conformationally constrained L-homocysteic acid analogs.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 10 | 4.81 | 6.60 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL575060 | GLUTAMIC ACID | 3.0 | 1 | 6.60 |
| CHEMBL231157 | — | — | 1 | 4.47 |
| CHEMBL389555 | — | — | 1 | 4.11 |
| CHEMBL230951 | — | — | 1 | 4.06 |
| CHEMBL389558 | — | — | 1 | - |
| CHEMBL230950 | — | — | 1 | - |
| CHEMBL389557 | — | — | 1 | - |
| CHEMBL230949 | — | — | 1 | - |
| CHEMBL389556 | — | — | 1 | - |
| CHEMBL230852 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL575060 | GLUTAMIC ACID | Ki | = | 250.0 | nM | 6.60 |
| CHEMBL231157 | — | Ki | = | 34000.0 | nM | 4.47 |
| CHEMBL389555 | — | Ki | = | 77000.0 | nM | 4.11 |
| CHEMBL230951 | — | Ki | = | 87000.0 | nM | 4.06 |
| CHEMBL389558 | — | Ki | > | 300000.0 | nM | - |
| CHEMBL230950 | — | Ki | > | 300000.0 | nM | - |
| CHEMBL389557 | — | Ki | > | 300000.0 | nM | - |
| CHEMBL230949 | — | Ki | > | 300000.0 | nM | - |
| CHEMBL389556 | — | Ki | > | 300000.0 | nM | - |
| CHEMBL230852 | — | Ki | = | 254000.0 | nM | - |