Assay Detail
Binding
CHEMBL895148
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H]kainic acid from rat KA receptor expressed in BHK cells
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Cell Type | BHK |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Synthesis, molecular modeling studies, and preliminary pharmacological characterization of all possible 2-(2'-sulfonocyclopropyl)glycine stereoisomers as conformationally constrained L-homocysteic acid analogs.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 10 | 4.92 | 7.16 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL575060 | GLUTAMIC ACID | 3.0 | 1 | 7.16 |
| CHEMBL389558 | — | — | 1 | 5.48 |
| CHEMBL230951 | — | — | 1 | 5.00 |
| CHEMBL389556 | — | — | 1 | 4.47 |
| CHEMBL389555 | — | — | 1 | 4.47 |
| CHEMBL230949 | — | — | 1 | 4.46 |
| CHEMBL230950 | — | — | 1 | 4.19 |
| CHEMBL230852 | — | — | 1 | 4.15 |
| CHEMBL389557 | — | — | 1 | - |
| CHEMBL231157 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL575060 | GLUTAMIC ACID | Ki | = | 70.0 | nM | 7.16 |
| CHEMBL389558 | — | Ki | = | 3300.0 | nM | 5.48 |
| CHEMBL230951 | — | Ki | = | 9900.0 | nM | 5.00 |
| CHEMBL389556 | — | Ki | = | 34000.0 | nM | 4.47 |
| CHEMBL389555 | — | Ki | = | 34000.0 | nM | 4.47 |
| CHEMBL230949 | — | Ki | = | 35000.0 | nM | 4.46 |
| CHEMBL230950 | — | Ki | = | 64000.0 | nM | 4.19 |
| CHEMBL230852 | — | Ki | = | 71000.0 | nM | 4.15 |
| CHEMBL389557 | — | Ki | > | 300000.0 | nM | - |
| CHEMBL231157 | — | Ki | > | 300000.0 | nM | - |