Assay Detail
Binding
CHEMBL895149
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Displacement of [3H]AMPA from rat AMPA receptor expressed in BHK cells
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Cell Type | BHK |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Synthesis, molecular modeling studies, and preliminary pharmacological characterization of all possible 2-(2'-sulfonocyclopropyl)glycine stereoisomers as conformationally constrained L-homocysteic acid analogs.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 10 | 5.34 | 7.10 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL575060 | GLUTAMIC ACID | 3.0 | 1 | 7.10 |
| CHEMBL389558 | — | — | 1 | 7.00 |
| CHEMBL230951 | — | — | 1 | 5.62 |
| CHEMBL230852 | — | — | 1 | 4.14 |
| CHEMBL230950 | — | — | 1 | 4.14 |
| CHEMBL389556 | — | — | 1 | 4.02 |
| CHEMBL389555 | — | — | 1 | - |
| CHEMBL230949 | — | — | 1 | - |
| CHEMBL389557 | — | — | 1 | - |
| CHEMBL231157 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL575060 | GLUTAMIC ACID | Ki | = | 80.0 | nM | 7.10 |
| CHEMBL389558 | — | Ki | = | 100.0 | nM | 7.00 |
| CHEMBL230951 | — | Ki | = | 2400.0 | nM | 5.62 |
| CHEMBL230852 | — | Ki | = | 72000.0 | nM | 4.14 |
| CHEMBL230950 | — | Ki | = | 72000.0 | nM | 4.14 |
| CHEMBL389556 | — | Ki | = | 96000.0 | nM | 4.02 |
| CHEMBL389555 | — | Ki | > | 300000.0 | nM | - |
| CHEMBL230949 | — | Ki | > | 300000.0 | nM | - |
| CHEMBL389557 | — | Ki | > | 300000.0 | nM | - |
| CHEMBL231157 | — | Ki | > | 300000.0 | nM | - |