Assay Detail
Functional
CHEMBL895162
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Antiproliferative activity against human HCT116 with KSP D130V mutant after 72 hrs
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HCT-116 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Novel ATP-competitive kinesin spindle protein inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 7.55 | 8.51 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL243669 | — | — | 1 | 8.51 |
| CHEMBL390629 | — | — | 1 | 8.27 |
| CHEMBL436624 | — | — | 1 | 5.86 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL243669 | — | IC50 | = | 3.1 | nM | 8.51 |
| CHEMBL390629 | — | IC50 | = | 5.4 | nM | 8.27 |
| CHEMBL436624 | — | IC50 | = | 1372.0 | nM | 5.86 |