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Assay Detail

CHEMBL895174

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of FAAH in rat cerebellum membranes assessed as [3H]anandamide hydrolysis
ChEMBL ↗
62
Total Activities
32
Compounds Tested
2
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Rattus norvegicus
Tissue Cerebellum
Subcellular Membrane
Confidence 9 — Direct single protein target
Curated By Intermediate

Target

Fatty-acid amide hydrolase 1 (CHEMBL3229) ↗
Type SINGLE PROTEIN
Organism Rattus norvegicus

Publication

Structure-activity relationship of a series of inhibitors of monoacylglycerol hydrolysis--comparison with effects upon fatty acid amide hydrolase.
Cisneros JA, Vandevoorde S, Ortega-Gutiérrez S, Paris C, Fowler CJ, López-Rodríguez ML.
J Med Chem (2007) 50 : 5012 -5023
PubMed 17764163 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Log I50 32 - -
IC50 30 4.65 5.80

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL396951 — — 2 5.80
CHEMBL230760 — — 2 5.28
CHEMBL243922 — — 2 5.22
CHEMBL397182 — — 2 5.12
CHEMBL230968 — — 2 5.09
CHEMBL230867 — — 2 5.00
CHEMBL231074 — — 2 5.00
CHEMBL230967 — — 2 4.96
CHEMBL287788 — — 2 4.96
CHEMBL244156 — — 2 4.92
CHEMBL395492 — — 2 4.92
CHEMBL243722 — — 2 4.77
CHEMBL231177 — — 2 4.75
CHEMBL230969 — — 2 4.72
CHEMBL425843 — — 2 4.68
CHEMBL244134 — — 2 4.55
CHEMBL230970 — — 2 4.54
CHEMBL231178 — — 2 4.50
CHEMBL287364 — — 2 4.48
CHEMBL231076 — — 2 4.46
CHEMBL231077 — — 2 4.37
CHEMBL230759 — — 2 4.29
CHEMBL231179 — — 2 4.28
CHEMBL287130 — — 2 4.25
CHEMBL395015 — — 2 4.21
CHEMBL244354 — — 2 4.16
CHEMBL243923 — — 2 4.05
CHEMBL230866 — — 2 4.04
CHEMBL230225 — — 2 4.01
CHEMBL388436 — — 2 4.00

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL396951 — IC50 = 1600.0 nM 5.80
CHEMBL230760 — IC50 = 5300.0 nM 5.28
CHEMBL243922 — IC50 = 6000.0 nM 5.22
CHEMBL397182 — IC50 = 7500.0 nM 5.12
CHEMBL230968 — IC50 = 8200.0 nM 5.09
CHEMBL230867 — IC50 = 10000.0 nM 5.00
CHEMBL231074 — IC50 = 10000.0 nM 5.00
CHEMBL287788 — IC50 = 11000.0 nM 4.96
CHEMBL230967 — IC50 = 11000.0 nM 4.96
CHEMBL244156 — IC50 = 12000.0 nM 4.92
CHEMBL395492 — IC50 = 12000.0 nM 4.92
CHEMBL243722 — IC50 = 17000.0 nM 4.77
CHEMBL231177 — IC50 = 18000.0 nM 4.75
CHEMBL230969 — IC50 = 19000.0 nM 4.72
CHEMBL425843 — IC50 = 21000.0 nM 4.68
CHEMBL244134 — IC50 = 28000.0 nM 4.55
CHEMBL230970 — IC50 = 29000.0 nM 4.54
CHEMBL231178 — IC50 = 32000.0 nM 4.50
CHEMBL287364 — IC50 = 33000.0 nM 4.48
CHEMBL231076 — IC50 = 35000.0 nM 4.46
CHEMBL231077 — IC50 = 43000.0 nM 4.37
CHEMBL230759 — IC50 = 51000.0 nM 4.29
CHEMBL231179 — IC50 = 53000.0 nM 4.28
CHEMBL287130 — IC50 = 56000.0 nM 4.25
CHEMBL395015 — IC50 = 61000.0 nM 4.21
CHEMBL244354 — IC50 = 69000.0 nM 4.16
CHEMBL243923 — IC50 = 90000.0 nM 4.05
CHEMBL230866 — IC50 = 91000.0 nM 4.04
CHEMBL230225 — IC50 = 98000.0 nM 4.01
CHEMBL388436 — IC50 = 99000.0 nM 4.00
CHEMBL231077 — Log I50 = 4.37 — -
CHEMBL231177 — Log I50 = 4.75 — -
CHEMBL231179 — Log I50 = 4.28 — -
CHEMBL231178 — Log I50 = 4.49 — -
CHEMBL244157 BENZOIC ACID 2,3-EPOXYPROPYL ESTER Log I50 < 4.0 — -
CHEMBL231074 — Log I50 = 5.0 — -
CHEMBL244156 — Log I50 = 4.91 — -
CHEMBL287364 — Log I50 = 4.48 — -
CHEMBL388436 — Log I50 = 4.01 — -
CHEMBL287788 — Log I50 = 4.98 — -
CHEMBL230225 — Log I50 = 4.0 — -
CHEMBL230968 — Log I50 = 5.09 — -
CHEMBL230760 — Log I50 = 5.3 — -
CHEMBL244354 — Log I50 = 4.16 — -
CHEMBL230759 — Log I50 = 4.3 — -
CHEMBL425843 — Log I50 = 4.68 — -
CHEMBL230866 — Log I50 = 4.0 — -
CHEMBL230867 — Log I50 = 5.0 — -
CHEMBL243722 — Log I50 = 4.76 — -
CHEMBL396951 — Log I50 = 5.8 — -