Assay Detail
Functional
CHEMBL895181
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiviral activity against HIV1 RF in human CEM-SS cells by XTT assay
39
Total Activities
39
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Human immunodeficiency virus 1 |
| Cell Type | CEM-SS |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Target
Human immunodeficiency virus 1 (CHEMBL378) ↗| Type | ORGANISM |
| Organism | Human immunodeficiency virus 1 |
Publication
Synthesis and biological evaluation of alkenyldiarylmethane HIV-1 non-nucleoside reverse transcriptase inhibitors that possess increased hydrolytic stability.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 23 | 6.48 | 9.00 |
| Activity | 16 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL107200 | — | — | 1 | 9.00 |
| CHEMBL223228 | EFAVIRENZ | 4.0 | 1 | 8.30 |
| CHEMBL294840 | — | — | 1 | 8.00 |
| CHEMBL57 | NEVIRAPINE | 4.0 | 1 | 7.82 |
| CHEMBL226735 | — | — | 1 | 7.52 |
| CHEMBL231470 | — | — | 1 | 7.40 |
| CHEMBL387567 | — | — | 1 | 7.30 |
| CHEMBL243068 | — | — | 1 | 6.44 |
| CHEMBL243277 | — | — | 1 | 6.37 |
| CHEMBL231274 | — | — | 1 | 6.30 |
| CHEMBL244780 | — | — | 1 | 6.28 |
| CHEMBL244781 | — | — | 1 | 6.22 |
| CHEMBL231275 | — | — | 1 | 6.22 |
| CHEMBL231175 | — | — | 1 | 6.01 |
| CHEMBL244999 | — | — | 1 | 5.68 |
| CHEMBL231072 | — | — | 1 | 5.66 |
| CHEMBL242844 | — | — | 1 | 5.64 |
| CHEMBL242843 | — | — | 1 | 5.62 |
| CHEMBL245218 | — | — | 1 | 5.58 |
| CHEMBL255525 | — | — | 1 | 5.54 |
| CHEMBL243066 | — | — | 1 | 5.52 |
| CHEMBL243067 | — | — | 1 | 5.52 |
| CHEMBL438127 | — | — | 1 | 5.19 |
| CHEMBL231377 | — | — | 1 | - |
| CHEMBL231376 | — | — | 1 | - |
| CHEMBL387804 | — | — | 1 | - |
| CHEMBL231375 | — | — | 1 | - |
| CHEMBL230966 | — | — | 1 | - |
| CHEMBL398202 | — | — | 1 | - |
| CHEMBL241996 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL107200 | — | EC50 | = | 1.0 | nM | 9.00 |
| CHEMBL223228 | EFAVIRENZ | EC50 | = | 5.0 | nM | 8.30 |
| CHEMBL294840 | — | EC50 | = | 10.0 | nM | 8.00 |
| CHEMBL57 | NEVIRAPINE | EC50 | = | 15.0 | nM | 7.82 |
| CHEMBL226735 | — | EC50 | = | 30.0 | nM | 7.52 |
| CHEMBL231470 | — | EC50 | = | 40.0 | nM | 7.40 |
| CHEMBL387567 | — | EC50 | = | 50.0 | nM | 7.30 |
| CHEMBL243068 | — | EC50 | = | 360.0 | nM | 6.44 |
| CHEMBL243277 | — | EC50 | = | 430.0 | nM | 6.37 |
| CHEMBL231274 | — | EC50 | = | 500.0 | nM | 6.30 |
| CHEMBL244780 | — | EC50 | = | 520.0 | nM | 6.28 |
| CHEMBL244781 | — | EC50 | = | 600.0 | nM | 6.22 |
| CHEMBL231275 | — | EC50 | = | 600.0 | nM | 6.22 |
| CHEMBL231175 | — | EC50 | = | 970.0 | nM | 6.01 |
| CHEMBL244999 | — | EC50 | = | 2100.0 | nM | 5.68 |
| CHEMBL231072 | — | EC50 | = | 2200.0 | nM | 5.66 |
| CHEMBL242844 | — | EC50 | = | 2300.0 | nM | 5.64 |
| CHEMBL242843 | — | EC50 | = | 2400.0 | nM | 5.62 |
| CHEMBL245218 | — | EC50 | = | 2600.0 | nM | 5.58 |
| CHEMBL255525 | — | EC50 | = | 2900.0 | nM | 5.54 |
| CHEMBL243067 | — | EC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL243066 | — | EC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL438127 | — | EC50 | = | 6400.0 | nM | 5.19 |
| CHEMBL3706913 | — | Activity | - | — | - | |
| CHEMBL231473 | — | Activity | - | — | - | |
| CHEMBL3706914 | — | Activity | - | — | - | |
| CHEMBL242845 | — | Activity | - | — | - | |
| CHEMBL555376 | — | Activity | - | — | - | |
| CHEMBL429286 | — | Activity | - | — | - | |
| CHEMBL244998 | — | Activity | - | — | - | |
| CHEMBL396233 | — | Activity | - | — | - | |
| CHEMBL398201 | — | Activity | - | — | - | |
| CHEMBL241996 | — | Activity | - | — | - | |
| CHEMBL398202 | — | Activity | - | — | - | |
| CHEMBL230966 | — | Activity | - | — | - | |
| CHEMBL231375 | — | Activity | - | — | - | |
| CHEMBL387804 | — | Activity | - | — | - | |
| CHEMBL231376 | — | Activity | - | — | - | |
| CHEMBL231377 | — | Activity | - | — | - |