Assay Detail
Functional
CHEMBL895183
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiviral activity against HIV2 ROD in human MT4 cells by XTT assay
39
Total Activities
39
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Human immunodeficiency virus 2 |
| Cell Type | MT4 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Target
Human immunodeficiency virus 2 (CHEMBL380) ↗| Type | ORGANISM |
| Organism | Human immunodeficiency virus 2 |
Publication
Synthesis and biological evaluation of alkenyldiarylmethane HIV-1 non-nucleoside reverse transcriptase inhibitors that possess increased hydrolytic stability.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Activity | 35 | - | - |
| EC50 | 4 | 5.05 | 5.33 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL244781 | — | — | 1 | 5.33 |
| CHEMBL396233 | — | — | 1 | 5.23 |
| CHEMBL294840 | — | — | 1 | 4.60 |
| CHEMBL231375 | — | — | 1 | - |
| CHEMBL387804 | — | — | 1 | - |
| CHEMBL231376 | — | — | 1 | - |
| CHEMBL231377 | — | — | 1 | - |
| CHEMBL231072 | — | — | 1 | - |
| CHEMBL387567 | — | — | 1 | - |
| CHEMBL231175 | — | — | 1 | - |
| CHEMBL231274 | — | — | 1 | - |
| CHEMBL107200 | — | — | 1 | - |
| CHEMBL223228 | EFAVIRENZ | 4.0 | 1 | - |
| CHEMBL57 | NEVIRAPINE | 4.0 | 1 | - |
| CHEMBL226735 | — | — | 1 | - |
| CHEMBL231470 | — | — | 1 | - |
| CHEMBL3706913 | — | — | 1 | - |
| CHEMBL255525 | — | — | 1 | - |
| CHEMBL3706914 | — | — | 1 | - |
| CHEMBL242843 | — | — | 1 | - |
| CHEMBL244999 | — | — | 1 | - |
| CHEMBL242845 | — | — | 1 | - |
| CHEMBL555376 | — | — | 1 | - |
| CHEMBL243066 | — | — | 1 | - |
| CHEMBL243067 | — | — | 1 | - |
| CHEMBL243068 | — | — | 1 | - |
| CHEMBL243277 | — | — | 1 | - |
| CHEMBL429286 | — | — | 1 | - |
| CHEMBL244780 | — | — | 1 | - |
| CHEMBL242844 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL244781 | — | EC50 | = | 4700.0 | nM | 5.33 |
| CHEMBL396233 | — | EC50 | = | 5900.0 | nM | 5.23 |
| CHEMBL294840 | — | EC50 | = | 25000.0 | nM | 4.60 |
| CHEMBL107200 | — | Activity | - | — | - | |
| CHEMBL244998 | — | Activity | - | — | - | |
| CHEMBL231274 | — | Activity | - | — | - | |
| CHEMBL231175 | — | Activity | - | — | - | |
| CHEMBL387567 | — | Activity | - | — | - | |
| CHEMBL231072 | — | Activity | - | — | - | |
| CHEMBL231377 | — | Activity | - | — | - | |
| CHEMBL231376 | — | Activity | - | — | - | |
| CHEMBL387804 | — | Activity | - | — | - | |
| CHEMBL231375 | — | Activity | - | — | - | |
| CHEMBL438127 | — | Activity | - | — | - | |
| CHEMBL231473 | — | Activity | - | — | - | |
| CHEMBL230966 | — | Activity | - | — | - | |
| CHEMBL398202 | — | Activity | - | — | - | |
| CHEMBL241996 | — | Activity | - | — | - | |
| CHEMBL398201 | — | Activity | - | — | - | |
| CHEMBL245218 | — | EC50 | - | — | - | |
| CHEMBL231275 | — | Activity | - | — | - | |
| CHEMBL242845 | — | Activity | - | — | - | |
| CHEMBL242844 | — | Activity | - | — | - | |
| CHEMBL244780 | — | Activity | - | — | - | |
| CHEMBL429286 | — | Activity | - | — | - | |
| CHEMBL243277 | — | Activity | - | — | - | |
| CHEMBL243068 | — | Activity | - | — | - | |
| CHEMBL243067 | — | Activity | - | — | - | |
| CHEMBL243066 | — | Activity | - | — | - | |
| CHEMBL555376 | — | Activity | - | — | - | |
| CHEMBL223228 | EFAVIRENZ | Activity | - | — | - | |
| CHEMBL244999 | — | Activity | - | — | - | |
| CHEMBL242843 | — | Activity | - | — | - | |
| CHEMBL3706914 | — | Activity | - | — | - | |
| CHEMBL255525 | — | Activity | - | — | - | |
| CHEMBL3706913 | — | Activity | - | — | - | |
| CHEMBL231470 | — | Activity | - | — | - | |
| CHEMBL226735 | — | Activity | - | — | - | |
| CHEMBL57 | NEVIRAPINE | Activity | - | — | - |