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Assay Detail

CHEMBL895188

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Antiviral activity against HIV1 with RT K103N mutation
15
Total Activities
15
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Human immunodeficiency virus 1
Confidence 1 — Organism
Curated By Intermediate

Target

Human immunodeficiency virus 1 (CHEMBL378)
Type ORGANISM
Organism Human immunodeficiency virus 1

Publication

Synthesis and biological evaluation of alkenyldiarylmethane HIV-1 non-nucleoside reverse transcriptase inhibitors that possess increased hydrolytic stability.
Cullen MD, Deng BL, Hartman TL, Watson KM, Buckheit RW, Pannecouque C, Clercq ED, Cushman M.
J Med Chem (2007) 50 : 4854 -4867
PubMed 17803290 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
EC50 15 6.01 6.40

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL387567 1 6.40
CHEMBL243068 1 6.10
CHEMBL244781 1 6.00
CHEMBL231274 1 5.92
CHEMBL231275 1 5.64
CHEMBL555376 1 -
CHEMBL231473 1 -
CHEMBL387804 1 -
CHEMBL231072 1 -
CHEMBL245218 1 -
CHEMBL244999 1 -
CHEMBL438127 1 -
CHEMBL244780 1 -
CHEMBL243277 1 -
CHEMBL243067 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL387567 EC50 = 400.0 nM 6.40
CHEMBL243068 EC50 = 800.0 nM 6.10
CHEMBL244781 EC50 = 1000.0 nM 6.00
CHEMBL231274 EC50 = 1200.0 nM 5.92
CHEMBL231275 EC50 = 2300.0 nM 5.64
CHEMBL555376 EC50 > 50000.0 nM -
CHEMBL231473 EC50 > 50000.0 nM -
CHEMBL387804 EC50 > 50000.0 nM -
CHEMBL231072 EC50 > 50000.0 nM -
CHEMBL245218 EC50 > 50000.0 nM -
CHEMBL244999 EC50 > 50000.0 nM -
CHEMBL438127 EC50 > 50000.0 nM -
CHEMBL244780 EC50 > 50000.0 nM -
CHEMBL243277 EC50 > 50000.0 nM -
CHEMBL243067 EC50 > 50000.0 nM -