Assay Detail
Binding
CHEMBL895213
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Binding affinity to 5HT1A receptor in rat cortex membrane
25
Total Activities
25
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Tissue | Cortex |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
High-efficacy 5-HT1A agonists for antidepressant treatment: a renewed opportunity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 25 | 8.21 | 9.37 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL231471 | — | — | 1 | 9.37 |
| CHEMBL425833 | — | — | 1 | 9.16 |
| CHEMBL396062 | — | — | 1 | 9.13 |
| CHEMBL45305 | BEFIRADOL | 2.0 | 1 | 9.07 |
| CHEMBL394530 | — | — | 1 | 8.92 |
| CHEMBL56 | 8-OH-DPAT | — | 1 | 8.85 |
| CHEMBL394606 | — | — | 1 | 8.76 |
| CHEMBL39 | SEROTONIN | 3.0 | 1 | 8.73 |
| CHEMBL230963 | — | — | 1 | 8.65 |
| CHEMBL394778 | — | — | 1 | 8.64 |
| CHEMBL231273 | — | — | 1 | 8.47 |
| CHEMBL230327 | — | — | 1 | 8.42 |
| CHEMBL231373 | — | — | 1 | 8.32 |
| CHEMBL230961 | — | — | 1 | 8.25 |
| CHEMBL231372 | — | — | 1 | 8.19 |
| CHEMBL230425 | — | — | 1 | 8.13 |
| CHEMBL231068 | FLIBANSERIN | 4.0 | 1 | 7.93 |
| CHEMBL231272 | — | — | 1 | 7.60 |
| CHEMBL209821 | NALUZOTAN | 3.0 | 1 | 7.52 |
| CHEMBL231271 | — | — | 1 | 7.25 |
| CHEMBL230962 | — | — | 1 | 7.18 |
| CHEMBL231069 | — | — | 1 | 7.02 |
| CHEMBL231172 | — | — | 1 | 6.93 |
| CHEMBL231170 | — | — | 1 | 6.66 |
| CHEMBL231262 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL231471 | — | Ki | = | 0.4266 | nM | 9.37 |
| CHEMBL425833 | — | Ki | = | 0.6918 | nM | 9.16 |
| CHEMBL396062 | — | Ki | = | 0.7413 | nM | 9.13 |
| CHEMBL45305 | BEFIRADOL | Ki | = | 0.8511 | nM | 9.07 |
| CHEMBL394530 | — | Ki | = | 1.202 | nM | 8.92 |
| CHEMBL56 | 8-OH-DPAT | Ki | = | 1.413 | nM | 8.85 |
| CHEMBL394606 | — | Ki | = | 1.738 | nM | 8.76 |
| CHEMBL39 | SEROTONIN | Ki | = | 1.862 | nM | 8.73 |
| CHEMBL230963 | — | Ki | = | 2.239 | nM | 8.65 |
| CHEMBL394778 | — | Ki | = | 2.291 | nM | 8.64 |
| CHEMBL231273 | — | Ki | = | 3.388 | nM | 8.47 |
| CHEMBL230327 | — | Ki | = | 3.802 | nM | 8.42 |
| CHEMBL231373 | — | Ki | = | 4.786 | nM | 8.32 |
| CHEMBL230961 | — | Ki | = | 5.623 | nM | 8.25 |
| CHEMBL231372 | — | Ki | = | 6.457 | nM | 8.19 |
| CHEMBL230425 | — | Ki | = | 7.413 | nM | 8.13 |
| CHEMBL231068 | FLIBANSERIN | Ki | = | 11.75 | nM | 7.93 |
| CHEMBL231272 | — | Ki | = | 25.12 | nM | 7.60 |
| CHEMBL209821 | NALUZOTAN | Ki | = | 30.2 | nM | 7.52 |
| CHEMBL231271 | — | Ki | = | 56.23 | nM | 7.25 |
| CHEMBL230962 | — | Ki | = | 66.07 | nM | 7.18 |
| CHEMBL231069 | — | Ki | = | 95.5 | nM | 7.02 |
| CHEMBL231172 | — | Ki | = | 117.49 | nM | 6.93 |
| CHEMBL231170 | — | Ki | = | 218.78 | nM | 6.66 |
| CHEMBL231262 | — | Ki | > | 10000.0 | nM | - |