Assay Detail
Functional
CHEMBL895214
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Agonist activity at human 5HT1A receptor expressed in C6 cells assessed as stimulation of [35S]GTPgammaS binding
19
Total Activities
19
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | C6 |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
High-efficacy 5-HT1A agonists for antidepressant treatment: a renewed opportunity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 19 | 6.70 | 8.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL231471 | — | — | 1 | 8.00 |
| CHEMBL45305 | BEFIRADOL | 2.0 | 1 | 7.63 |
| CHEMBL56 | 8-OH-DPAT | — | 1 | 7.49 |
| CHEMBL396062 | — | — | 1 | 7.37 |
| CHEMBL425833 | — | — | 1 | 7.16 |
| CHEMBL394606 | — | — | 1 | 7.07 |
| CHEMBL394778 | — | — | 1 | 7.05 |
| CHEMBL209821 | NALUZOTAN | 3.0 | 1 | 7.03 |
| CHEMBL231273 | — | — | 1 | 6.81 |
| CHEMBL39 | SEROTONIN | 3.0 | 1 | 6.64 |
| CHEMBL394530 | — | — | 1 | 6.64 |
| CHEMBL230327 | — | — | 1 | 6.62 |
| CHEMBL231373 | — | — | 1 | 6.51 |
| CHEMBL230963 | — | — | 1 | 6.41 |
| CHEMBL231372 | — | — | 1 | 6.35 |
| CHEMBL231068 | FLIBANSERIN | 4.0 | 1 | 6.20 |
| CHEMBL230425 | — | — | 1 | 5.69 |
| CHEMBL231272 | — | — | 1 | 5.44 |
| CHEMBL230961 | — | — | 1 | 5.10 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL231471 | — | EC50 | = | 10.0 | nM | 8.00 |
| CHEMBL45305 | BEFIRADOL | EC50 | = | 23.44 | nM | 7.63 |
| CHEMBL56 | 8-OH-DPAT | EC50 | = | 32.36 | nM | 7.49 |
| CHEMBL396062 | — | EC50 | = | 42.66 | nM | 7.37 |
| CHEMBL425833 | — | EC50 | = | 69.18 | nM | 7.16 |
| CHEMBL394606 | — | EC50 | = | 85.11 | nM | 7.07 |
| CHEMBL394778 | — | EC50 | = | 89.13 | nM | 7.05 |
| CHEMBL209821 | NALUZOTAN | EC50 | = | 93.33 | nM | 7.03 |
| CHEMBL231273 | — | EC50 | = | 154.88 | nM | 6.81 |
| CHEMBL39 | SEROTONIN | EC50 | = | 229.09 | nM | 6.64 |
| CHEMBL394530 | — | EC50 | = | 229.09 | nM | 6.64 |
| CHEMBL230327 | — | EC50 | = | 239.88 | nM | 6.62 |
| CHEMBL231373 | — | EC50 | = | 309.03 | nM | 6.51 |
| CHEMBL230963 | — | EC50 | = | 389.05 | nM | 6.41 |
| CHEMBL231372 | — | EC50 | = | 446.68 | nM | 6.35 |
| CHEMBL231068 | FLIBANSERIN | EC50 | = | 630.96 | nM | 6.20 |
| CHEMBL230425 | — | EC50 | = | 2041.74 | nM | 5.69 |
| CHEMBL231272 | — | EC50 | = | 3630.78 | nM | 5.44 |
| CHEMBL230961 | — | EC50 | = | 7943.28 | nM | 5.10 |