Assay Detail
Binding
CHEMBL895227
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Inhibition of rat brain mitochondria MAOB by radioenzymatic assay
22
Total Activities
22
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Subcellular | Mitochondria |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Target
Amine oxidase [flavin-containing] B (CHEMBL2993) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
Solid-phase synthesis and insights into structure-activity relationships of safinamide analogues as potent and selective inhibitors of type B monoamine oxidase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 22 | 6.10 | 7.77 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL243733 | — | — | 1 | 7.77 |
| CHEMBL242618 | — | — | 1 | 7.48 |
| CHEMBL394347 | — | — | 1 | 7.37 |
| CHEMBL396778 | SAFINAMIDE | 4.0 | 1 | 7.01 |
| CHEMBL244771 | — | — | 1 | 6.96 |
| CHEMBL243059 | — | — | 1 | 6.85 |
| CHEMBL243512 | — | — | 1 | 6.62 |
| CHEMBL352004 | — | — | 1 | 6.58 |
| CHEMBL156994 | — | — | 1 | 6.47 |
| CHEMBL243058 | — | — | 1 | 6.39 |
| CHEMBL82327 | — | — | 1 | 6.35 |
| CHEMBL242835 | — | — | 1 | 6.10 |
| CHEMBL243077 | — | — | 1 | 5.96 |
| CHEMBL397987 | — | — | 1 | 5.66 |
| CHEMBL231583 | — | — | 1 | 5.65 |
| CHEMBL348597 | — | — | 1 | 5.50 |
| CHEMBL243079 | — | — | 1 | 5.15 |
| CHEMBL396267 | — | — | 1 | 5.15 |
| CHEMBL242409 | — | — | 1 | 5.04 |
| CHEMBL243081 | — | — | 1 | 5.00 |
| CHEMBL243082 | — | — | 1 | 5.00 |
| CHEMBL243080 | — | — | 1 | 4.13 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL243733 | — | IC50 | = | 17.0 | nM | 7.77 |
| CHEMBL242618 | — | IC50 | = | 33.0 | nM | 7.48 |
| CHEMBL394347 | — | IC50 | = | 43.0 | nM | 7.37 |
| CHEMBL396778 | SAFINAMIDE | IC50 | = | 98.0 | nM | 7.01 |
| CHEMBL244771 | — | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL243059 | — | IC50 | = | 140.0 | nM | 6.85 |
| CHEMBL243512 | — | IC50 | = | 240.0 | nM | 6.62 |
| CHEMBL352004 | — | IC50 | = | 260.0 | nM | 6.58 |
| CHEMBL156994 | — | IC50 | = | 340.0 | nM | 6.47 |
| CHEMBL243058 | — | IC50 | = | 410.0 | nM | 6.39 |
| CHEMBL82327 | — | IC50 | = | 450.0 | nM | 6.35 |
| CHEMBL242835 | — | IC50 | = | 800.0 | nM | 6.10 |
| CHEMBL243077 | — | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL397987 | — | IC50 | = | 2200.0 | nM | 5.66 |
| CHEMBL231583 | — | IC50 | = | 2240.0 | nM | 5.65 |
| CHEMBL348597 | — | IC50 | = | 3150.0 | nM | 5.50 |
| CHEMBL243079 | — | IC50 | = | 7010.0 | nM | 5.15 |
| CHEMBL396267 | — | IC50 | = | 7100.0 | nM | 5.15 |
| CHEMBL242409 | — | IC50 | = | 9100.0 | nM | 5.04 |
| CHEMBL243081 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL243082 | — | IC50 | = | 10100.0 | nM | 5.00 |
| CHEMBL243080 | — | IC50 | = | 73800.0 | nM | 4.13 |