Assay Detail
Functional
CHEMBL895332
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Agonist activity at adrenergic beta-2 receptor in guinea pig tracheal rings assessed as myorelaxing activity on carbachol-induced contraction in presence of 1H-[1,2,4]oxadiazolo-[4,3-a]quinoxalin-1-one
7
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Cavia porcellus |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Nitric oxide donor beta2-agonists: furoxan derivatives containing the fenoterol moiety and related furazans.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 7 | 6.75 | 7.77 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL244687 | — | — | 2 | 7.77 |
| CHEMBL32800 | FENOTEROL | 4.0 | 1 | 7.72 |
| CHEMBL243266 | — | — | 2 | 6.89 |
| CHEMBL395082 | — | — | 2 | 6.64 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL244687 | — | EC50 | = | 17.0 | nM | 7.77 |
| CHEMBL32800 | FENOTEROL | EC50 | = | 19.0 | nM | 7.72 |
| CHEMBL243266 | — | EC50 | = | 130.0 | nM | 6.89 |
| CHEMBL395082 | — | EC50 | = | 230.0 | nM | 6.64 |
| CHEMBL244687 | — | EC50 | = | 440.0 | nM | 6.36 |
| CHEMBL243266 | — | EC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL395082 | — | EC50 | = | 1200.0 | nM | 5.92 |