Assay Detail
Functional
CHEMBL895334
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Vasodilating activity against phenylephrine-induced contraction in rat thoracic aorta in presence of 1H-[1,2,4]oxadiazolo-[4,3-a]quinoxalin-1-one
5
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Rattus norvegicus |
| Tissue | Thoracic aorta |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Nitric oxide donor beta2-agonists: furoxan derivatives containing the fenoterol moiety and related furazans.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 5 | 5.51 | 6.07 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL244687 | — | — | 2 | 6.07 |
| CHEMBL363325 | — | — | 1 | 5.92 |
| CHEMBL243266 | — | — | 2 | 4.85 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL244687 | — | EC50 | = | 860.0 | nM | 6.07 |
| CHEMBL363325 | — | EC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL244687 | — | EC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL243266 | — | EC50 | = | 14000.0 | nM | 4.85 |
| CHEMBL243266 | — | EC50 | = | 16000.0 | nM | 4.80 |