Assay Detail
Functional
CHEMBL895342
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Vasodilating activity against phenylephrine-induced contractions in rat thoracic aorta
9
Total Activities
6
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Rattus norvegicus |
| Tissue | Thoracic aorta |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Nitric oxide donor beta2-agonists: furoxan derivatives containing the fenoterol moiety and related furazans.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 8 | 6.26 | 7.92 |
| Activity | 1 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL363325 | — | — | 1 | 7.92 |
| CHEMBL244687 | — | — | 2 | 7.85 |
| CHEMBL243266 | — | — | 2 | 5.92 |
| CHEMBL206100 | — | — | 1 | 5.20 |
| CHEMBL395082 | — | — | 2 | 4.75 |
| CHEMBL32800 | FENOTEROL | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL363325 | — | EC50 | = | 12.0 | nM | 7.92 |
| CHEMBL244687 | — | EC50 | = | 14.0 | nM | 7.85 |
| CHEMBL244687 | — | EC50 | = | 14.0 | nM | 7.85 |
| CHEMBL243266 | — | EC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL243266 | — | EC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL206100 | — | EC50 | = | 6300.0 | nM | 5.20 |
| CHEMBL395082 | — | EC50 | = | 18000.0 | nM | 4.75 |
| CHEMBL395082 | — | EC50 | = | 20000.0 | nM | 4.70 |
| CHEMBL32800 | FENOTEROL | Activity | - | — | - |