Assay Detail
Binding
CHEMBL895358
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of bovine aldose reductase
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Bos taurus |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Target
Aldo-keto reductase family 1 member B1 (CHEMBL3081) ↗| Type | SINGLE PROTEIN |
| Organism | Bos taurus |
Publication
Evaluation of in vitro aldose redutase inhibitory activity of 5-arylidene-2,4-thiazolidinediones.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 6.17 | 6.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL396176 | — | — | 1 | 6.70 |
| CHEMBL233577 | — | — | 1 | 6.64 |
| CHEMBL233782 | — | — | 1 | 6.58 |
| CHEMBL1076861 | — | — | 1 | 6.25 |
| CHEMBL233575 | — | — | 1 | 6.22 |
| CHEMBL396175 | — | — | 1 | 6.16 |
| CHEMBL266497 | SORBINIL | 3.0 | 1 | 5.85 |
| CHEMBL232380 | — | — | 1 | 4.93 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL396176 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL233577 | — | IC50 | = | 230.0 | nM | 6.64 |
| CHEMBL233782 | — | IC50 | = | 260.0 | nM | 6.58 |
| CHEMBL1076861 | — | IC50 | = | 560.0 | nM | 6.25 |
| CHEMBL233575 | — | IC50 | = | 600.0 | nM | 6.22 |
| CHEMBL396175 | — | IC50 | = | 700.0 | nM | 6.16 |
| CHEMBL266497 | SORBINIL | IC50 | = | 1410.0 | nM | 5.85 |
| CHEMBL232380 | — | IC50 | = | 11800.0 | nM | 4.93 |