Assay Detail
Binding
CHEMBL895407
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Inhibition of human recombinant acetylcholinesterase
34
Total Activities
34
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Publication
Novel class of quinone-bearing polyamines as multi-target-directed ligands to combat Alzheimer's disease.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 34 | 7.12 | 8.65 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL243271 | — | — | 1 | 8.65 |
| CHEMBL230702 | — | — | 1 | 8.63 |
| CHEMBL243062 | — | — | 1 | 8.57 |
| CHEMBL243056 | — | — | 1 | 8.52 |
| CHEMBL243055 | — | — | 1 | 8.29 |
| CHEMBL243273 | — | — | 1 | 8.11 |
| CHEMBL243269 | — | — | 1 | 8.02 |
| CHEMBL242836 | — | — | 1 | 7.89 |
| CHEMBL243272 | — | — | 1 | 7.87 |
| CHEMBL394865 | — | — | 1 | 7.86 |
| CHEMBL394348 | — | — | 1 | 7.76 |
| CHEMBL502 | DONEPEZIL | 4.0 | 1 | 7.64 |
| CHEMBL230434 | — | — | 1 | 7.37 |
| CHEMBL242661 | — | — | 1 | 7.29 |
| CHEMBL390247 | — | — | 1 | 7.22 |
| CHEMBL243270 | — | — | 1 | 7.21 |
| CHEMBL243274 | — | — | 1 | 7.14 |
| CHEMBL218443 | — | — | 1 | 7.13 |
| CHEMBL242191 | — | — | 1 | 7.11 |
| CHEMBL243044 | — | — | 1 | 6.91 |
| CHEMBL396050 | — | — | 1 | 6.91 |
| CHEMBL244762 | — | — | 1 | 6.90 |
| CHEMBL241974 | — | — | 1 | 6.88 |
| CHEMBL276444 | — | — | 1 | 6.84 |
| CHEMBL557586 | CAPROCTAMINE HCL | — | 1 | 6.77 |
| CHEMBL241960 | — | — | 1 | 6.72 |
| CHEMBL95 | TACRINE | 4.0 | 1 | 6.37 |
| CHEMBL243057 | — | — | 1 | 6.23 |
| CHEMBL659 | GALANTAMINE | 4.0 | 1 | 5.70 |
| CHEMBL395815 | — | — | 1 | 5.64 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL243271 | — | IC50 | = | 2.25 | nM | 8.65 |
| CHEMBL230702 | — | IC50 | = | 2.36 | nM | 8.63 |
| CHEMBL243062 | — | IC50 | = | 2.66 | nM | 8.57 |
| CHEMBL243056 | — | IC50 | = | 3.05 | nM | 8.52 |
| CHEMBL243055 | — | IC50 | = | 5.17 | nM | 8.29 |
| CHEMBL243273 | — | IC50 | = | 7.79 | nM | 8.11 |
| CHEMBL243269 | — | IC50 | = | 9.5 | nM | 8.02 |
| CHEMBL242836 | — | IC50 | = | 12.9 | nM | 7.89 |
| CHEMBL243272 | — | IC50 | = | 13.6 | nM | 7.87 |
| CHEMBL394865 | — | IC50 | = | 13.8 | nM | 7.86 |
| CHEMBL394348 | — | IC50 | = | 17.3 | nM | 7.76 |
| CHEMBL502 | DONEPEZIL | IC50 | = | 23.1 | nM | 7.64 |
| CHEMBL230434 | — | IC50 | = | 42.5 | nM | 7.37 |
| CHEMBL242661 | — | IC50 | = | 51.1 | nM | 7.29 |
| CHEMBL390247 | — | IC50 | = | 60.4 | nM | 7.22 |
| CHEMBL243270 | — | IC50 | = | 61.5 | nM | 7.21 |
| CHEMBL243274 | — | IC50 | = | 71.9 | nM | 7.14 |
| CHEMBL218443 | — | IC50 | = | 73.3 | nM | 7.13 |
| CHEMBL242191 | — | IC50 | = | 77.8 | nM | 7.11 |
| CHEMBL243044 | — | IC50 | = | 123.0 | nM | 6.91 |
| CHEMBL396050 | — | IC50 | = | 123.0 | nM | 6.91 |
| CHEMBL244762 | — | IC50 | = | 125.0 | nM | 6.90 |
| CHEMBL241974 | — | IC50 | = | 133.0 | nM | 6.88 |
| CHEMBL276444 | — | IC50 | = | 144.0 | nM | 6.84 |
| CHEMBL557586 | CAPROCTAMINE HCL | IC50 | = | 170.0 | nM | 6.77 |
| CHEMBL241960 | — | IC50 | = | 192.0 | nM | 6.72 |
| CHEMBL95 | TACRINE | IC50 | = | 424.0 | nM | 6.37 |
| CHEMBL243057 | — | IC50 | = | 593.0 | nM | 6.23 |
| CHEMBL659 | GALANTAMINE | IC50 | = | 2010.0 | nM | 5.70 |
| CHEMBL395815 | — | IC50 | = | 2310.0 | nM | 5.64 |
| CHEMBL636 | RIVASTIGMINE | IC50 | = | 3030.0 | nM | 5.52 |
| CHEMBL242190 | — | IC50 | = | 11600.0 | nM | 4.94 |
| CHEMBL345124 | PROPIDIUM | IC50 | = | 32300.0 | nM | 4.49 |
| CHEMBL429694 | CONGO RED | IC50 | - | — | - |