Assay Detail
Binding
CHEMBL895408
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human recombinant butyrylcholinesterase
34
Total Activities
34
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Publication
Novel class of quinone-bearing polyamines as multi-target-directed ligands to combat Alzheimer's disease.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 34 | 5.53 | 7.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL636 | RIVASTIGMINE | 4.0 | 1 | 7.52 |
| CHEMBL95 | TACRINE | 4.0 | 1 | 7.34 |
| CHEMBL243269 | — | — | 1 | 6.33 |
| CHEMBL230434 | — | — | 1 | 6.30 |
| CHEMBL394348 | — | — | 1 | 6.29 |
| CHEMBL218443 | — | — | 1 | 6.19 |
| CHEMBL242836 | — | — | 1 | 6.18 |
| CHEMBL243062 | — | — | 1 | 6.16 |
| CHEMBL243056 | — | — | 1 | 6.10 |
| CHEMBL243273 | — | — | 1 | 5.90 |
| CHEMBL243055 | — | — | 1 | 5.82 |
| CHEMBL394865 | — | — | 1 | 5.77 |
| CHEMBL243274 | — | — | 1 | 5.68 |
| CHEMBL396050 | — | — | 1 | 5.65 |
| CHEMBL242661 | — | — | 1 | 5.62 |
| CHEMBL244762 | — | — | 1 | 5.61 |
| CHEMBL390247 | — | — | 1 | 5.55 |
| CHEMBL243044 | — | — | 1 | 5.49 |
| CHEMBL276444 | — | — | 1 | 5.47 |
| CHEMBL230702 | — | — | 1 | 5.46 |
| CHEMBL242191 | — | — | 1 | 5.29 |
| CHEMBL502 | DONEPEZIL | 4.0 | 1 | 5.13 |
| CHEMBL243271 | — | — | 1 | 5.01 |
| CHEMBL557586 | CAPROCTAMINE HCL | — | 1 | 4.94 |
| CHEMBL241974 | — | — | 1 | 4.92 |
| CHEMBL243272 | — | — | 1 | 4.89 |
| CHEMBL345124 | PROPIDIUM | — | 1 | 4.88 |
| CHEMBL243270 | — | — | 1 | 4.78 |
| CHEMBL242190 | — | — | 1 | 4.73 |
| CHEMBL659 | GALANTAMINE | 4.0 | 1 | 4.68 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL636 | RIVASTIGMINE | IC50 | = | 30.1 | nM | 7.52 |
| CHEMBL95 | TACRINE | IC50 | = | 45.8 | nM | 7.34 |
| CHEMBL243269 | — | IC50 | = | 462.0 | nM | 6.33 |
| CHEMBL230434 | — | IC50 | = | 505.0 | nM | 6.30 |
| CHEMBL394348 | — | IC50 | = | 518.0 | nM | 6.29 |
| CHEMBL218443 | — | IC50 | = | 645.0 | nM | 6.19 |
| CHEMBL242836 | — | IC50 | = | 660.0 | nM | 6.18 |
| CHEMBL243062 | — | IC50 | = | 696.0 | nM | 6.16 |
| CHEMBL243056 | — | IC50 | = | 800.0 | nM | 6.10 |
| CHEMBL243273 | — | IC50 | = | 1250.0 | nM | 5.90 |
| CHEMBL243055 | — | IC50 | = | 1520.0 | nM | 5.82 |
| CHEMBL394865 | — | IC50 | = | 1690.0 | nM | 5.77 |
| CHEMBL243274 | — | IC50 | = | 2080.0 | nM | 5.68 |
| CHEMBL396050 | — | IC50 | = | 2250.0 | nM | 5.65 |
| CHEMBL242661 | — | IC50 | = | 2390.0 | nM | 5.62 |
| CHEMBL244762 | — | IC50 | = | 2470.0 | nM | 5.61 |
| CHEMBL390247 | — | IC50 | = | 2790.0 | nM | 5.55 |
| CHEMBL243044 | — | IC50 | = | 3230.0 | nM | 5.49 |
| CHEMBL276444 | — | IC50 | = | 3410.0 | nM | 5.47 |
| CHEMBL230702 | — | IC50 | = | 3460.0 | nM | 5.46 |
| CHEMBL242191 | — | IC50 | = | 5110.0 | nM | 5.29 |
| CHEMBL502 | DONEPEZIL | IC50 | = | 7420.0 | nM | 5.13 |
| CHEMBL243271 | — | IC50 | = | 9840.0 | nM | 5.01 |
| CHEMBL557586 | CAPROCTAMINE HCL | IC50 | = | 11600.0 | nM | 4.94 |
| CHEMBL241974 | — | IC50 | = | 11900.0 | nM | 4.92 |
| CHEMBL243272 | — | IC50 | = | 12800.0 | nM | 4.89 |
| CHEMBL345124 | PROPIDIUM | IC50 | = | 13200.0 | nM | 4.88 |
| CHEMBL243270 | — | IC50 | = | 16800.0 | nM | 4.78 |
| CHEMBL242190 | — | IC50 | = | 18500.0 | nM | 4.73 |
| CHEMBL659 | GALANTAMINE | IC50 | = | 20700.0 | nM | 4.68 |
| CHEMBL243057 | — | IC50 | = | 45100.0 | nM | 4.35 |
| CHEMBL395815 | — | IC50 | = | 67100.0 | nM | 4.17 |
| CHEMBL241960 | — | IC50 | = | 70100.0 | nM | 4.15 |
| CHEMBL429694 | CONGO RED | IC50 | - | — | - |