Assay Detail
Binding
CHEMBL895425
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Binding affinity to human CB1 receptor
27
Total Activities
27
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
2-Arylimino-5,6-dihydro-4H-1,3-thiazines as a new class of cannabinoid receptor agonists. Part 2: orally bioavailable compounds.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 27 | 6.72 | 7.89 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL231721 | — | — | 1 | 7.89 |
| CHEMBL232116 | — | — | 1 | 7.82 |
| CHEMBL465 | DRONABINOL | 4.0 | 1 | 7.77 |
| CHEMBL232328 | — | — | 1 | 7.52 |
| CHEMBL232336 | — | — | 1 | 7.36 |
| CHEMBL233139 | — | — | 1 | 7.07 |
| CHEMBL392842 | — | — | 1 | 7.02 |
| CHEMBL231719 | — | — | 1 | 7.00 |
| CHEMBL231932 | — | — | 1 | 6.97 |
| CHEMBL232132 | — | — | 1 | 6.94 |
| CHEMBL443842 | — | — | 1 | 6.91 |
| CHEMBL393045 | — | — | 1 | 6.76 |
| CHEMBL232538 | — | — | 1 | 6.61 |
| CHEMBL234175 | — | — | 1 | 6.61 |
| CHEMBL232130 | — | — | 1 | 6.45 |
| CHEMBL232118 | — | — | 1 | 6.40 |
| CHEMBL232131 | — | — | 1 | 6.38 |
| CHEMBL231934 | — | — | 1 | 6.29 |
| CHEMBL232929 | — | — | 1 | 6.27 |
| CHEMBL231933 | — | — | 1 | 6.17 |
| CHEMBL393188 | — | — | 1 | 6.15 |
| CHEMBL398145 | — | — | 1 | 6.12 |
| CHEMBL392841 | — | — | 1 | 5.90 |
| CHEMBL232129 | — | — | 1 | 5.82 |
| CHEMBL231935 | — | — | 1 | 5.76 |
| CHEMBL391561 | — | — | 1 | - |
| CHEMBL232730 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL231721 | — | Ki | = | 13.0 | nM | 7.89 |
| CHEMBL232116 | — | Ki | = | 15.0 | nM | 7.82 |
| CHEMBL465 | DRONABINOL | Ki | = | 17.0 | nM | 7.77 |
| CHEMBL232328 | — | Ki | = | 30.0 | nM | 7.52 |
| CHEMBL232336 | — | Ki | = | 44.0 | nM | 7.36 |
| CHEMBL233139 | — | Ki | = | 85.0 | nM | 7.07 |
| CHEMBL392842 | — | Ki | = | 95.0 | nM | 7.02 |
| CHEMBL231719 | — | Ki | = | 100.0 | nM | 7.00 |
| CHEMBL231932 | — | Ki | = | 108.0 | nM | 6.97 |
| CHEMBL232132 | — | Ki | = | 114.0 | nM | 6.94 |
| CHEMBL443842 | — | Ki | = | 122.0 | nM | 6.91 |
| CHEMBL393045 | — | Ki | = | 173.0 | nM | 6.76 |
| CHEMBL232538 | — | Ki | = | 246.0 | nM | 6.61 |
| CHEMBL234175 | — | Ki | = | 243.0 | nM | 6.61 |
| CHEMBL232130 | — | Ki | = | 358.0 | nM | 6.45 |
| CHEMBL232118 | — | Ki | = | 396.0 | nM | 6.40 |
| CHEMBL232131 | — | Ki | = | 418.0 | nM | 6.38 |
| CHEMBL231934 | — | Ki | = | 514.0 | nM | 6.29 |
| CHEMBL232929 | — | Ki | = | 541.0 | nM | 6.27 |
| CHEMBL231933 | — | Ki | = | 671.0 | nM | 6.17 |
| CHEMBL393188 | — | Ki | = | 711.0 | nM | 6.15 |
| CHEMBL398145 | — | Ki | = | 763.0 | nM | 6.12 |
| CHEMBL392841 | — | Ki | = | 1260.0 | nM | 5.90 |
| CHEMBL232129 | — | Ki | = | 1500.0 | nM | 5.82 |
| CHEMBL231935 | — | Ki | = | 1730.0 | nM | 5.76 |
| CHEMBL391561 | — | Ki | > | 5000.0 | nM | - |
| CHEMBL232730 | — | Ki | > | 5000.0 | nM | - |