Assay Detail
Binding
CHEMBL895448
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [125I]apamin from SK channel in Wistar rat cortex
19
Total Activities
19
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Confidence | 5 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Target
Small conductance calcium-activated potassium channel (CHEMBL2096673) ↗| Type | PROTEIN FAMILY |
| Organism | Rattus norvegicus |
Publication
Synthesis and radioligand binding studies of bis-isoquinolinium derivatives as small conductance Ca(2+)-activated K(+) channel blockers.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 19 | 6.67 | 7.64 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL397282 | — | — | 1 | 7.64 |
| CHEMBL394773 | — | — | 1 | 7.48 |
| CHEMBL395568 | — | — | 1 | 7.46 |
| CHEMBL242790 | — | — | 1 | 7.38 |
| CHEMBL242789 | — | — | 1 | 7.05 |
| CHEMBL241952 | — | — | 1 | 6.97 |
| CHEMBL242791 | — | — | 1 | 6.88 |
| CHEMBL242579 | — | — | 1 | 6.82 |
| CHEMBL242578 | — | — | 1 | 6.79 |
| CHEMBL241953 | — | — | 1 | 6.79 |
| CHEMBL390923 | — | — | 1 | 6.71 |
| CHEMBL121663 | DEQUALINIUM CHLORIDE | 4.0 | 1 | 6.66 |
| CHEMBL244261 | — | — | 1 | 6.55 |
| CHEMBL390924 | — | — | 1 | 6.36 |
| CHEMBL241951 | — | — | 1 | 5.96 |
| CHEMBL215370 | LAUDANOSINE METHIODIDE | — | 1 | 5.89 |
| CHEMBL242577 | — | — | 1 | 5.83 |
| CHEMBL242372 | — | — | 1 | 5.77 |
| CHEMBL429280 | — | — | 1 | 5.71 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL397282 | — | Ki | = | 23.0 | nM | 7.64 |
| CHEMBL394773 | — | Ki | = | 33.0 | nM | 7.48 |
| CHEMBL395568 | — | Ki | = | 35.0 | nM | 7.46 |
| CHEMBL242790 | — | Ki | = | 42.0 | nM | 7.38 |
| CHEMBL242789 | — | Ki | = | 90.0 | nM | 7.05 |
| CHEMBL241952 | — | Ki | = | 106.0 | nM | 6.97 |
| CHEMBL242791 | — | Ki | = | 132.0 | nM | 6.88 |
| CHEMBL242579 | — | Ki | = | 150.0 | nM | 6.82 |
| CHEMBL242578 | — | Ki | = | 164.0 | nM | 6.79 |
| CHEMBL241953 | — | Ki | = | 163.0 | nM | 6.79 |
| CHEMBL390923 | — | Ki | = | 196.0 | nM | 6.71 |
| CHEMBL121663 | DEQUALINIUM CHLORIDE | Ki | = | 221.0 | nM | 6.66 |
| CHEMBL244261 | — | Ki | = | 280.0 | nM | 6.55 |
| CHEMBL390924 | — | Ki | = | 438.0 | nM | 6.36 |
| CHEMBL241951 | — | Ki | = | 1103.0 | nM | 5.96 |
| CHEMBL215370 | LAUDANOSINE METHIODIDE | Ki | = | 1295.0 | nM | 5.89 |
| CHEMBL242577 | — | Ki | = | 1465.0 | nM | 5.83 |
| CHEMBL242372 | — | Ki | = | 1687.0 | nM | 5.77 |
| CHEMBL429280 | — | Ki | = | 1962.0 | nM | 5.71 |