Assay Detail
Binding
CHEMBL895449
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Blockade of SK channel in Wistar rat brain assessed as inhibition of apamin-sensitive after-hyperpolarisation
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Confidence | 5 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Target
Small conductance calcium-activated potassium channel (CHEMBL2096673) ↗| Type | PROTEIN FAMILY |
| Organism | Rattus norvegicus |
Publication
Synthesis and radioligand binding studies of bis-isoquinolinium derivatives as small conductance Ca(2+)-activated K(+) channel blockers.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 5.32 | 5.62 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL397282 | — | — | 1 | 5.62 |
| CHEMBL394773 | — | — | 1 | 5.42 |
| CHEMBL395568 | — | — | 1 | 5.39 |
| CHEMBL242790 | — | — | 1 | 5.36 |
| CHEMBL215370 | LAUDANOSINE METHIODIDE | — | 1 | 4.82 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL397282 | — | IC50 | = | 2400.0 | nM | 5.62 |
| CHEMBL394773 | — | IC50 | = | 3800.0 | nM | 5.42 |
| CHEMBL395568 | — | IC50 | = | 4100.0 | nM | 5.39 |
| CHEMBL242790 | — | IC50 | = | 4400.0 | nM | 5.36 |
| CHEMBL215370 | LAUDANOSINE METHIODIDE | IC50 | = | 15000.0 | nM | 4.82 |