Assay Detail
Binding
CHEMBL895622
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Displacement of [3H]DOI from 5HT2B receptor expressed in CHO cells
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | CHO |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Principal component analysis differentiates the receptor binding profiles of three antipsychotic drug candidates from current antipsychotic drugs.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 3 | 6.83 | 7.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL71 | CHLORPROMAZINE | 4.0 | 1 | 7.40 |
| CHEMBL716 | QUETIAPINE | 4.0 | 1 | 6.60 |
| CHEMBL243712 | AMISULPRIDE | 4.0 | 1 | 6.50 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL71 | CHLORPROMAZINE | Ki | = | 39.81 | nM | 7.40 |
| CHEMBL716 | QUETIAPINE | Ki | = | 251.19 | nM | 6.60 |
| CHEMBL243712 | AMISULPRIDE | Ki | = | 316.23 | nM | 6.50 |