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Assay Detail

CHEMBL895723

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Displacement of [3H]SCH 23390 from human dopamine D1 receptor
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Confidence 9 — Direct single protein target
Curated By Expert

Target

D(1A) dopamine receptor (CHEMBL2056)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Dopamine/serotonin receptor ligands. 16.(1) Expanding dibenz[d,g]azecines to 11- and 12-membered homologues. Interaction with dopamine D(1)-D(5) receptors.
Enzensperger C, Müller FK, Schmalwasser B, Wiecha P, Traber H, Lehmann J.
J Med Chem (2007) 50 : 4528 -4533
PubMed 17676831 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 13 7.31 8.49

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL231070 1 8.49
CHEMBL389356 1 7.86
CHEMBL276778 1 7.73
CHEMBL231171 1 7.63
CHEMBL389357 1 7.53
CHEMBL394779 1 7.16
CHEMBL389559 1 7.08
CHEMBL231374 1 6.86
CHEMBL396950 1 6.54
CHEMBL397207 1 6.24
CHEMBL394777 1 -
CHEMBL397180 1 -
CHEMBL443843 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL231070 Ki = 3.2 nM 8.49
CHEMBL389356 Ki = 13.9 nM 7.86
CHEMBL276778 Ki = 18.5 nM 7.73
CHEMBL231171 Ki = 23.5 nM 7.63
CHEMBL389357 Ki = 29.4 nM 7.53
CHEMBL394779 Ki = 70.0 nM 7.16
CHEMBL389559 Ki = 83.0 nM 7.08
CHEMBL231374 Ki = 137.0 nM 6.86
CHEMBL396950 Ki = 291.0 nM 6.54
CHEMBL397207 Ki = 579.0 nM 6.24
CHEMBL394777 Ki > 10000.0 nM -
CHEMBL397180 Ki > 10000.0 nM -
CHEMBL443843 Ki > 10000.0 nM -