Assay Detail
Binding
CHEMBL895743
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Inhibition of tubulin polymerization in presence of microtubule associated proteins after 30 mins
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 5 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Publication
4- and 5-aroylindoles as novel classes of potent antitubulin agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 5.77 | 5.96 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL230741 | — | — | 1 | 5.96 |
| CHEMBL230846 | — | — | 1 | 5.92 |
| CHEMBL67 | COMBRETASTATIN A4 | -1.0 | 1 | 5.89 |
| CHEMBL230747 | — | — | 1 | 5.75 |
| CHEMBL395786 | — | — | 1 | 5.72 |
| CHEMBL230738 | — | — | 1 | 5.70 |
| CHEMBL395785 | — | — | 1 | 5.66 |
| CHEMBL107 | COLCHICINE | 4.0 | 1 | 5.54 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL230741 | — | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL230846 | — | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL67 | COMBRETASTATIN A4 | IC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL230747 | — | IC50 | = | 1800.0 | nM | 5.75 |
| CHEMBL395786 | — | IC50 | = | 1900.0 | nM | 5.72 |
| CHEMBL230738 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL395785 | — | IC50 | = | 2200.0 | nM | 5.66 |
| CHEMBL107 | COLCHICINE | IC50 | = | 2900.0 | nM | 5.54 |