Assay Detail
Functional
CHEMBL895746
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Growth inhibition of SK-Mel2 melanoma cells after 48 hrs by MTT assay
33
Total Activities
32
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | SK-MEL-2 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Structural analogues of smoothened intracellular loops as potent inhibitors of Hedgehog pathway and cancer cell growth.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 33 | 6.61 | 9.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL396373 | — | — | 1 | 9.52 |
| CHEMBL266584 | — | — | 1 | 9.40 |
| CHEMBL438326 | — | — | 1 | 8.22 |
| CHEMBL266358 | — | — | 1 | 7.30 |
| CHEMBL396529 | — | — | 1 | 7.22 |
| CHEMBL439316 | — | — | 1 | 7.10 |
| CHEMBL397982 | — | — | 1 | 7.05 |
| CHEMBL397759 | — | — | 1 | 7.00 |
| CHEMBL232287 | — | — | 1 | 6.70 |
| CHEMBL262801 | — | — | 1 | 6.52 |
| CHEMBL437939 | — | — | 1 | 6.35 |
| CHEMBL267728 | — | — | 1 | 6.35 |
| CHEMBL430358 | — | — | 1 | 6.30 |
| CHEMBL428018 | — | — | 1 | 6.30 |
| CHEMBL429789 | — | — | 1 | 6.19 |
| CHEMBL233485 | — | — | 1 | 6.16 |
| CHEMBL438302 | — | — | 2 | 6.10 |
| CHEMBL438582 | — | — | 1 | 6.05 |
| CHEMBL389763 | — | — | 1 | 6.02 |
| CHEMBL266987 | — | — | 1 | 6.02 |
| CHEMBL437771 | — | — | 1 | 6.00 |
| CHEMBL428546 | — | — | 1 | 6.00 |
| CHEMBL438573 | — | — | 1 | 5.85 |
| CHEMBL428796 | — | — | 1 | 5.82 |
| CHEMBL395060 | — | — | 1 | 5.57 |
| CHEMBL233905 | — | — | 1 | 5.55 |
| CHEMBL428897 | — | — | 1 | - |
| CHEMBL2372048 | — | — | 1 | - |
| CHEMBL391811 | — | — | 1 | - |
| CHEMBL395299 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL396373 | — | IC50 | = | 0.3 | nM | 9.52 |
| CHEMBL266584 | — | IC50 | = | 0.4 | nM | 9.40 |
| CHEMBL438326 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL266358 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL396529 | — | IC50 | = | 60.0 | nM | 7.22 |
| CHEMBL439316 | — | IC50 | = | 80.0 | nM | 7.10 |
| CHEMBL397982 | — | IC50 | = | 90.0 | nM | 7.05 |
| CHEMBL397759 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL232287 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL262801 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL437939 | — | IC50 | = | 450.0 | nM | 6.35 |
| CHEMBL267728 | — | IC50 | = | 450.0 | nM | 6.35 |
| CHEMBL430358 | — | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL428018 | — | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL429789 | — | IC50 | = | 640.0 | nM | 6.19 |
| CHEMBL233485 | — | IC50 | = | 700.0 | nM | 6.16 |
| CHEMBL438302 | — | IC50 | = | 800.0 | nM | 6.10 |
| CHEMBL438582 | — | IC50 | = | 900.0 | nM | 6.05 |
| CHEMBL389763 | — | IC50 | = | 950.0 | nM | 6.02 |
| CHEMBL266987 | — | IC50 | = | 950.0 | nM | 6.02 |
| CHEMBL437771 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL428546 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL438302 | — | IC50 | = | 1330.0 | nM | 5.88 |
| CHEMBL438573 | — | IC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL428796 | — | IC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL395060 | — | IC50 | = | 2700.0 | nM | 5.57 |
| CHEMBL233905 | — | IC50 | = | 2800.0 | nM | 5.55 |
| CHEMBL428897 | — | IC50 | > | 5000.0 | nM | - |
| CHEMBL395299 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL391811 | — | IC50 | > | 5000.0 | nM | - |
| CHEMBL437184 | — | IC50 | > | 15000.0 | nM | - |
| CHEMBL2372047 | — | IC50 | > | 15000.0 | nM | - |
| CHEMBL2372048 | — | IC50 | > | 15000.0 | nM | - |