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Assay Detail

CHEMBL895775

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Functional
Antimalarial activity against Plasmodium falciparum D6
ChEMBL ↗
60
Total Activities
22
Compounds Tested
2
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Plasmodium falciparum
Confidence 1 — Organism
Curated By Intermediate

Target

Plasmodium falciparum (CHEMBL364) ↗
Type ORGANISM
Organism Plasmodium falciparum

Publication

Deoxycholic acid-derived tetraoxane antimalarials and antiproliferatives(1).
Terzić N, Opsenica D, Milić D, Tinant B, Smith KS, Milhous WK, Solaja BA.
J Med Chem (2007) 50 : 5118 -5127
PubMed 17887664 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 30 7.46 8.26
IC90 30 - -

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL243890 — — 4 8.26
CHEMBL269067 — — 2 8.17
CHEMBL269671 ARTEMISININ 3.0 2 8.05
CHEMBL397724 — — 4 8.01
CHEMBL416956 MEFLOQUINE 4.0 2 7.98
CHEMBL389098 — — 4 7.94
CHEMBL443226 — — 4 7.89
CHEMBL245160 — — 4 7.87
CHEMBL76 CHLOROQUINE 4.0 2 7.75
CHEMBL410156 — — 4 7.73
CHEMBL410155 — — 4 7.63
CHEMBL388254 — — 2 7.55
CHEMBL243597 — — 2 7.49
CHEMBL388890 — — 4 7.42
CHEMBL244417 — — 2 7.13
CHEMBL245154 — — 2 6.98
CHEMBL396285 — — 2 6.97
CHEMBL397286 — — 2 6.88
CHEMBL243454 — — 2 6.75
CHEMBL243436 — — 2 6.70
CHEMBL244523 — — 2 6.66
CHEMBL3138356 — — 2 6.46

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL243890 — IC50 = 5.48 nM 8.26
CHEMBL269067 — IC50 = 6.7 nM 8.17
CHEMBL269671 ARTEMISININ IC50 = 9.0 nM 8.05
CHEMBL397724 — IC50 = 9.81 nM 8.01
CHEMBL416956 MEFLOQUINE IC50 = 10.52 nM 7.98
CHEMBL389098 — IC50 = 11.55 nM 7.94
CHEMBL443226 — IC50 = 12.83 nM 7.89
CHEMBL245160 — IC50 = 13.62 nM 7.87
CHEMBL76 CHLOROQUINE IC50 = 17.63 nM 7.75
CHEMBL410156 — IC50 = 18.63 nM 7.73
CHEMBL389098 — IC50 = 19.21 nM 7.72
CHEMBL243890 — IC50 = 19.78 nM 7.70
CHEMBL245160 — IC50 = 22.89 nM 7.64
CHEMBL410155 — IC50 = 23.32 nM 7.63
CHEMBL388254 — IC50 = 28.18 nM 7.55
CHEMBL397724 — IC50 = 29.29 nM 7.53
CHEMBL243597 — IC50 = 32.72 nM 7.49
CHEMBL388890 — IC50 = 37.95 nM 7.42
CHEMBL388890 — IC50 = 39.2 nM 7.41
CHEMBL410156 — IC50 = 43.82 nM 7.36
CHEMBL410155 — IC50 = 49.99 nM 7.30
CHEMBL244417 — IC50 = 74.28 nM 7.13
CHEMBL245154 — IC50 = 105.56 nM 6.98
CHEMBL443226 — IC50 = 104.14 nM 6.98
CHEMBL396285 — IC50 = 106.73 nM 6.97
CHEMBL397286 — IC50 = 133.24 nM 6.88
CHEMBL243454 — IC50 = 178.86 nM 6.75
CHEMBL243436 — IC50 = 201.43 nM 6.70
CHEMBL244523 — IC50 = 221.21 nM 6.66
CHEMBL3138356 — IC50 = 346.75 nM 6.46
CHEMBL244523 — IC90 - — -
CHEMBL397286 — IC90 = 195.48 nM -
CHEMBL243454 — IC90 = 197.37 nM -
CHEMBL245154 — IC90 = 131.4 nM -
CHEMBL3138356 — IC90 - — -
CHEMBL269067 — IC90 = 11.7 nM -
CHEMBL388254 — IC90 = 45.14 nM -
CHEMBL269671 ARTEMISININ IC90 = 12.8 nM -
CHEMBL243436 — IC90 = 258.37 nM -
CHEMBL244417 — IC90 = 115.17 nM -
CHEMBL243890 — IC90 = 29.2 nM -
CHEMBL397724 — IC90 = 39.26 nM -
CHEMBL245160 — IC90 = 18.98 nM -
CHEMBL443226 — IC90 = 148.09 nM -
CHEMBL388890 — IC90 = 62.88 nM -
CHEMBL245160 — IC90 = 31.35 nM -
CHEMBL76 CHLOROQUINE IC90 = 13.72 nM -
CHEMBL410156 — IC90 = 71.16 nM -
CHEMBL389098 — IC90 = 31.69 nM -
CHEMBL410155 — IC90 = 77.45 nM -