Assay Detail
Binding
CHEMBL895927
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Inhibition of human NHE1 expressed in PS120 cells
40
Total Activities
40
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | PS120 |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Publication
3-Substituted-(5-arylfuran-2-ylcarbonyl)guanidines as NHE-1 inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 40 | 6.52 | 9.32 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL392093 | — | — | 1 | 9.32 |
| CHEMBL394633 | — | — | 1 | 8.10 |
| CHEMBL395897 | — | — | 1 | 8.05 |
| CHEMBL232748 | — | — | 1 | 8.00 |
| CHEMBL395898 | — | — | 1 | 7.92 |
| CHEMBL232940 | — | — | 1 | 7.82 |
| CHEMBL397141 | — | — | 1 | 7.80 |
| CHEMBL232974 | — | — | 1 | 7.62 |
| CHEMBL396615 | — | — | 1 | 7.62 |
| CHEMBL232744 | — | — | 1 | 7.14 |
| CHEMBL233778 | — | — | 1 | 7.02 |
| CHEMBL395667 | — | — | 1 | 6.92 |
| CHEMBL233154 | — | — | 1 | 6.92 |
| CHEMBL232355 | — | — | 1 | 6.92 |
| CHEMBL232558 | — | — | 1 | 6.89 |
| CHEMBL232124 | — | — | 1 | 6.82 |
| CHEMBL231927 | — | — | 1 | 6.82 |
| CHEMBL232975 | — | — | 1 | 6.64 |
| CHEMBL398144 | — | — | 1 | 6.62 |
| CHEMBL391171 | — | — | 1 | 6.39 |
| CHEMBL392311 | — | — | 1 | 6.32 |
| CHEMBL441127 | — | — | 1 | 6.17 |
| CHEMBL231929 | — | — | 1 | 6.11 |
| CHEMBL396616 | — | — | 1 | 6.09 |
| CHEMBL395900 | — | — | 1 | 6.09 |
| CHEMBL231926 | — | — | 1 | 5.92 |
| CHEMBL436559 | CARIPORIDE | 2.0 | 1 | 5.92 |
| CHEMBL398143 | — | — | 1 | 5.64 |
| CHEMBL231784 | — | — | 1 | 5.52 |
| CHEMBL233354 | — | — | 1 | 5.35 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL392093 | — | IC50 | = | 0.48 | nM | 9.32 |
| CHEMBL394633 | — | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL395897 | — | IC50 | = | 9.0 | nM | 8.05 |
| CHEMBL232748 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL395898 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL232940 | — | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL397141 | — | IC50 | = | 16.0 | nM | 7.80 |
| CHEMBL232974 | — | IC50 | = | 24.0 | nM | 7.62 |
| CHEMBL396615 | — | IC50 | = | 24.0 | nM | 7.62 |
| CHEMBL232744 | — | IC50 | = | 72.0 | nM | 7.14 |
| CHEMBL233778 | — | IC50 | = | 96.0 | nM | 7.02 |
| CHEMBL395667 | — | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL232355 | — | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL233154 | — | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL232558 | — | IC50 | = | 130.0 | nM | 6.89 |
| CHEMBL232124 | — | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL231927 | — | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL232975 | — | IC50 | = | 230.0 | nM | 6.64 |
| CHEMBL398144 | — | IC50 | = | 240.0 | nM | 6.62 |
| CHEMBL391171 | — | IC50 | = | 410.0 | nM | 6.39 |
| CHEMBL392311 | — | IC50 | = | 480.0 | nM | 6.32 |
| CHEMBL441127 | — | IC50 | = | 680.0 | nM | 6.17 |
| CHEMBL231929 | — | IC50 | = | 770.0 | nM | 6.11 |
| CHEMBL396616 | — | IC50 | = | 820.0 | nM | 6.09 |
| CHEMBL395900 | — | IC50 | = | 820.0 | nM | 6.09 |
| CHEMBL231926 | — | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL436559 | CARIPORIDE | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL398143 | — | IC50 | = | 2300.0 | nM | 5.64 |
| CHEMBL231784 | — | IC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL233354 | — | IC50 | = | 4500.0 | nM | 5.35 |
| CHEMBL233779 | — | IC50 | = | 5100.0 | nM | 5.29 |
| CHEMBL232976 | — | IC50 | = | 5600.0 | nM | 5.25 |
| CHEMBL233353 | — | IC50 | = | 6200.0 | nM | 5.21 |
| CHEMBL443584 | — | IC50 | = | 14000.0 | nM | 4.85 |
| CHEMBL233352 | — | IC50 | = | 14000.0 | nM | 4.85 |
| CHEMBL233780 | — | IC50 | = | 16000.0 | nM | 4.80 |
| CHEMBL232180 | — | IC50 | = | 33000.0 | nM | 4.48 |
| CHEMBL232179 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL395395 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL231982 | — | IC50 | > | 30000.0 | nM | - |