Assay Detail
Functional
CHEMBL895985
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Antiviral activity against HIV1 infected MT4 cells by MTT method
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Human immunodeficiency virus 1 |
| Cell Type | MT4 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Target
Human immunodeficiency virus 1 (CHEMBL378) ↗| Type | ORGANISM |
| Organism | Human immunodeficiency virus 1 |
Publication
Design and synthesis of HIV-1 protease inhibitors incorporating oxazolidinones as P2/P2' ligands in pseudosymmetric dipeptide isosteres.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 12 | 6.76 | 8.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL729 | LOPINAVIR | 4.0 | 1 | 8.00 |
| CHEMBL114 | SAQUINAVIR | 4.0 | 1 | 8.00 |
| CHEMBL116 | AMPRENAVIR | 4.0 | 1 | 7.40 |
| CHEMBL245003 | — | — | 1 | 6.44 |
| CHEMBL388901 | — | — | 1 | 6.21 |
| CHEMBL388680 | — | — | 1 | 6.10 |
| CHEMBL230771 | — | — | 1 | 5.99 |
| CHEMBL245221 | — | — | 1 | 5.92 |
| CHEMBL395064 | — | — | 1 | - |
| CHEMBL388689 | — | — | 1 | - |
| CHEMBL1163 | ATAZANAVIR | 4.0 | 1 | - |
| CHEMBL163 | RITONAVIR | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL729 | LOPINAVIR | EC50 | = | 10.0 | nM | 8.00 |
| CHEMBL114 | SAQUINAVIR | EC50 | = | 10.0 | nM | 8.00 |
| CHEMBL116 | AMPRENAVIR | EC50 | = | 40.0 | nM | 7.40 |
| CHEMBL245003 | — | EC50 | = | 360.0 | nM | 6.44 |
| CHEMBL388901 | — | EC50 | = | 620.0 | nM | 6.21 |
| CHEMBL388680 | — | EC50 | = | 790.0 | nM | 6.10 |
| CHEMBL230771 | — | EC50 | = | 1030.0 | nM | 5.99 |
| CHEMBL245221 | — | EC50 | = | 1210.0 | nM | 5.92 |
| CHEMBL395064 | — | EC50 | - | — | - | |
| CHEMBL388689 | — | EC50 | - | — | - | |
| CHEMBL1163 | ATAZANAVIR | EC50 | - | — | - | |
| CHEMBL163 | RITONAVIR | EC50 | - | — | - |