Assay Detail

CHEMBL896022

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Functional

Growth inhibition of human HL60(TB) cells after 48 hrs by crystal violet assay

ChEMBL ↗

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Target

NON-PROTEIN TARGET (CHEMBL3879801) ↗

Open DB target context

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Primary target NON-PROTEIN TARGET

CHEMBL3879801

Anchored from Assay target.

Protein identity NON-PROTEIN TARGET

Disease frame Disease evidence pending

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Review focus Open DB context pending

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Total Activities

Compounds Tested

Activity Types

Assay Parameters

Assay Information

Assay Type	Functional
Organism	Homo sapiens
Cell Type	HL-60(TB)
Confidence	1 — Organism
Curated By	Autocuration

Target

NON-PROTEIN TARGET (CHEMBL3879801) ↗

Type	NON-MOLECULAR

Publication

Doxazolidine induction of apoptosis by a topoisomerase II independent mechanism.

Kalet BT, McBryde MB, Espinosa JM, Koch TH.
J Med Chem (2007) 50 : 4493 -4500
PubMed 17696516 · DOI

Activity Statistics

Type	Count	Avg pChEMBL	Best pChEMBL
IC50	2	8.36	9.48

Compounds Tested

Compound	Name	Phase	Activities	Best pChEMBL
CHEMBL217089	DOXAZOLIDINE	—	1	9.48
CHEMBL53463	DOXORUBICIN	4.0	1	7.23

Activity Data

Compound	Name	Type	Rel.	Value	Units	pChEMBL
CHEMBL217089	DOXAZOLIDINE	IC50	=	0.3311	nM	9.48
CHEMBL53463	DOXORUBICIN	IC50	=	58.88	nM	7.23