Assay Detail
Binding
CHEMBL896126
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Inhibition of human recombinant PTP1B
46
Total Activities
46
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Target
Tyrosine-protein phosphatase non-receptor type 1 (CHEMBL335) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Structure-based optimization of protein tyrosine phosphatase 1B inhibitors: from the active site to the second phosphotyrosine binding site.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 46 | 7.18 | 9.17 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL244563 | — | — | 1 | 9.17 |
| CHEMBL395722 | — | — | 1 | 9.00 |
| CHEMBL230862 | — | — | 1 | 8.70 |
| CHEMBL230860 | — | — | 1 | 8.70 |
| CHEMBL243268 | — | — | 1 | 8.52 |
| CHEMBL397415 | — | — | 1 | 8.52 |
| CHEMBL243267 | — | — | 1 | 8.52 |
| CHEMBL541214 | — | — | 1 | 8.40 |
| CHEMBL390245 | — | — | 1 | 8.40 |
| CHEMBL387614 | — | — | 1 | 8.40 |
| CHEMBL230645 | — | — | 1 | 8.30 |
| CHEMBL230752 | — | — | 1 | 8.22 |
| CHEMBL230751 | — | — | 1 | 8.22 |
| CHEMBL230325 | — | — | 1 | 8.15 |
| CHEMBL244361 | — | — | 1 | 8.10 |
| CHEMBL390244 | — | — | 1 | 8.00 |
| CHEMBL230543 | — | — | 1 | 7.89 |
| CHEMBL397903 | — | — | 1 | 7.85 |
| CHEMBL244564 | — | — | 1 | 7.62 |
| CHEMBL243942 | — | — | 1 | 7.44 |
| CHEMBL230643 | — | — | 1 | 7.42 |
| CHEMBL244148 | — | — | 1 | 7.36 |
| CHEMBL244360 | — | — | 1 | 7.26 |
| CHEMBL388426 | — | — | 1 | 7.13 |
| CHEMBL243941 | — | — | 1 | 6.92 |
| CHEMBL396554 | — | — | 1 | 6.72 |
| CHEMBL243732 | — | — | 1 | 6.70 |
| CHEMBL243940 | — | — | 1 | 6.68 |
| CHEMBL396555 | — | — | 1 | 6.52 |
| CHEMBL429105 | — | — | 1 | 6.51 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL244563 | — | Ki | = | 0.68 | nM | 9.17 |
| CHEMBL395722 | — | Ki | = | 1.0 | nM | 9.00 |
| CHEMBL230860 | — | Ki | = | 2.0 | nM | 8.70 |
| CHEMBL230862 | — | Ki | = | 2.0 | nM | 8.70 |
| CHEMBL243268 | — | Ki | = | 3.0 | nM | 8.52 |
| CHEMBL397415 | — | Ki | = | 3.0 | nM | 8.52 |
| CHEMBL243267 | — | Ki | = | 3.0 | nM | 8.52 |
| CHEMBL541214 | — | Ki | = | 4.0 | nM | 8.40 |
| CHEMBL390245 | — | Ki | = | 4.0 | nM | 8.40 |
| CHEMBL387614 | — | Ki | = | 4.0 | nM | 8.40 |
| CHEMBL230645 | — | Ki | = | 5.0 | nM | 8.30 |
| CHEMBL230752 | — | Ki | = | 6.0 | nM | 8.22 |
| CHEMBL230751 | — | Ki | = | 6.0 | nM | 8.22 |
| CHEMBL230325 | — | Ki | = | 7.0 | nM | 8.15 |
| CHEMBL244361 | — | Ki | = | 8.0 | nM | 8.10 |
| CHEMBL390244 | — | Ki | = | 10.0 | nM | 8.00 |
| CHEMBL230543 | — | Ki | = | 13.0 | nM | 7.89 |
| CHEMBL397903 | — | Ki | = | 14.0 | nM | 7.85 |
| CHEMBL244564 | — | Ki | = | 24.0 | nM | 7.62 |
| CHEMBL243942 | — | Ki | = | 36.0 | nM | 7.44 |
| CHEMBL230643 | — | Ki | = | 38.0 | nM | 7.42 |
| CHEMBL244148 | — | Ki | = | 44.0 | nM | 7.36 |
| CHEMBL244360 | — | Ki | = | 55.0 | nM | 7.26 |
| CHEMBL388426 | — | Ki | = | 74.0 | nM | 7.13 |
| CHEMBL243941 | — | Ki | = | 120.0 | nM | 6.92 |
| CHEMBL396554 | — | Ki | = | 190.0 | nM | 6.72 |
| CHEMBL243732 | — | Ki | = | 200.0 | nM | 6.70 |
| CHEMBL243940 | — | Ki | = | 210.0 | nM | 6.68 |
| CHEMBL396555 | — | Ki | = | 300.0 | nM | 6.52 |
| CHEMBL429105 | — | Ki | = | 310.0 | nM | 6.51 |
| CHEMBL394853 | — | Ki | = | 310.0 | nM | 6.51 |
| CHEMBL244147 | — | Ki | = | 390.0 | nM | 6.41 |
| CHEMBL394852 | — | Ki | = | 390.0 | nM | 6.41 |
| CHEMBL397255 | — | Ki | = | 440.0 | nM | 6.36 |
| CHEMBL243731 | — | Ki | = | 470.0 | nM | 6.33 |
| CHEMBL394851 | — | Ki | = | 680.0 | nM | 6.17 |
| CHEMBL213662 | — | Ki | = | 1000.0 | nM | 6.00 |
| CHEMBL243508 | — | Ki | = | 1700.0 | nM | 5.77 |
| CHEMBL388425 | — | Ki | = | 2000.0 | nM | 5.70 |
| CHEMBL243730 | — | Ki | = | 2000.0 | nM | 5.70 |
| CHEMBL243509 | — | Ki | = | 2000.0 | nM | 5.70 |
| CHEMBL243510 | — | Ki | = | 2100.0 | nM | 5.68 |
| CHEMBL397254 | — | Ki | = | 2100.0 | nM | 5.68 |
| CHEMBL213758 | — | Ki | = | 3200.0 | nM | 5.50 |
| CHEMBL244146 | — | Ki | = | 3800.0 | nM | 5.42 |
| CHEMBL397253 | — | Ki | = | 4000.0 | nM | 5.40 |