Assay Detail
Binding
CHEMBL896127
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Inhibition of human recombinant TCPTP
17
Total Activities
17
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Target
Tyrosine-protein phosphatase non-receptor type 2 (CHEMBL3807) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Structure-based optimization of protein tyrosine phosphatase 1B inhibitors: from the active site to the second phosphotyrosine binding site.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 17 | 8.13 | 8.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL230862 | — | — | 1 | 8.70 |
| CHEMBL230860 | — | — | 1 | 8.70 |
| CHEMBL230751 | — | — | 1 | 8.70 |
| CHEMBL395722 | — | — | 1 | 8.70 |
| CHEMBL230645 | — | — | 1 | 8.40 |
| CHEMBL541214 | — | — | 1 | 8.30 |
| CHEMBL397415 | — | — | 1 | 8.30 |
| CHEMBL243267 | — | — | 1 | 8.30 |
| CHEMBL387614 | — | — | 1 | 8.22 |
| CHEMBL390245 | — | — | 1 | 8.22 |
| CHEMBL230752 | — | — | 1 | 8.10 |
| CHEMBL243268 | — | — | 1 | 8.05 |
| CHEMBL390244 | — | — | 1 | 8.05 |
| CHEMBL230643 | — | — | 1 | 8.00 |
| CHEMBL397903 | — | — | 1 | 7.92 |
| CHEMBL243942 | — | — | 1 | 7.58 |
| CHEMBL213758 | — | — | 1 | 5.89 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL230862 | — | Ki | = | 2.0 | nM | 8.70 |
| CHEMBL230860 | — | Ki | = | 2.0 | nM | 8.70 |
| CHEMBL230751 | — | Ki | = | 2.0 | nM | 8.70 |
| CHEMBL395722 | — | Ki | = | 2.0 | nM | 8.70 |
| CHEMBL230645 | — | Ki | = | 4.0 | nM | 8.40 |
| CHEMBL541214 | — | Ki | = | 5.0 | nM | 8.30 |
| CHEMBL397415 | — | Ki | = | 5.0 | nM | 8.30 |
| CHEMBL243267 | — | Ki | = | 5.0 | nM | 8.30 |
| CHEMBL387614 | — | Ki | = | 6.0 | nM | 8.22 |
| CHEMBL390245 | — | Ki | = | 6.0 | nM | 8.22 |
| CHEMBL230752 | — | Ki | = | 8.0 | nM | 8.10 |
| CHEMBL243268 | — | Ki | = | 9.0 | nM | 8.05 |
| CHEMBL390244 | — | Ki | = | 9.0 | nM | 8.05 |
| CHEMBL230643 | — | Ki | = | 10.0 | nM | 8.00 |
| CHEMBL397903 | — | Ki | = | 12.0 | nM | 7.92 |
| CHEMBL243942 | — | Ki | = | 26.0 | nM | 7.58 |
| CHEMBL213758 | — | Ki | = | 1300.0 | nM | 5.89 |