Assay Detail
Functional
CHEMBL896154
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Agonist activity at human GR expressed in CV1 cells by GRE activation assay
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | CV-1 |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Publication
Synthesis and characterization of nonsteroidal glucocorticoid receptor modulators for multiple myeloma.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 13 | 9.35 | 10.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL397920 | — | — | 1 | 10.00 |
| CHEMBL384467 | DEXAMETHASONE | 4.0 | 1 | 9.70 |
| CHEMBL395717 | — | — | 1 | 9.70 |
| CHEMBL395716 | — | — | 1 | 9.70 |
| CHEMBL394369 | — | — | 1 | 9.70 |
| CHEMBL243455 | — | — | 1 | 9.52 |
| CHEMBL244714 | — | — | 1 | 9.40 |
| CHEMBL428922 | — | — | 1 | 9.30 |
| CHEMBL429466 | — | — | 1 | 9.30 |
| CHEMBL244535 | — | — | 1 | 9.22 |
| CHEMBL244715 | — | — | 1 | 8.85 |
| CHEMBL243469 | — | — | 1 | 8.80 |
| CHEMBL397919 | — | — | 1 | 8.30 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL397920 | — | EC50 | = | 0.1 | nM | 10.00 |
| CHEMBL384467 | DEXAMETHASONE | EC50 | = | 0.2 | nM | 9.70 |
| CHEMBL395717 | — | EC50 | = | 0.2 | nM | 9.70 |
| CHEMBL395716 | — | EC50 | = | 0.2 | nM | 9.70 |
| CHEMBL394369 | — | EC50 | = | 0.2 | nM | 9.70 |
| CHEMBL243455 | — | EC50 | = | 0.3 | nM | 9.52 |
| CHEMBL244714 | — | EC50 | = | 0.4 | nM | 9.40 |
| CHEMBL428922 | — | EC50 | = | 0.5 | nM | 9.30 |
| CHEMBL429466 | — | EC50 | = | 0.5 | nM | 9.30 |
| CHEMBL244535 | — | EC50 | = | 0.6 | nM | 9.22 |
| CHEMBL244715 | — | EC50 | = | 1.4 | nM | 8.85 |
| CHEMBL243469 | — | EC50 | = | 1.6 | nM | 8.80 |
| CHEMBL397919 | — | EC50 | = | 5.0 | nM | 8.30 |