Assay Detail
Binding
CHEMBL896184
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Displacement of [3H]DTG from sigma2 receptor in Wistar rat liver membrane in presence of 1 uM [3H]pentazocine
14
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Tissue | Liver |
| Subcellular | Membrane |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Design and evaluation of naphthol- and carbazole-containing fluorescent sigma ligands as potential probes for receptor binding studies.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 14 | 7.04 | 8.08 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL538089 | — | — | 1 | 8.08 |
| CHEMBL535857 | — | — | 1 | 8.04 |
| CHEMBL535856 | — | — | 1 | 8.03 |
| CHEMBL535634 | — | — | 1 | 7.93 |
| CHEMBL536305 | — | — | 1 | 7.90 |
| CHEMBL541390 | — | — | 1 | 7.58 |
| CHEMBL282433 | DITOLYLGUANIDINE | — | 1 | 7.51 |
| CHEMBL538091 | — | — | 1 | 6.93 |
| CHEMBL558572 | — | — | 1 | 6.38 |
| CHEMBL555969 | — | — | 1 | 6.28 |
| CHEMBL537696 | — | — | 1 | 6.22 |
| CHEMBL535410 | — | — | 1 | 6.19 |
| CHEMBL535636 | — | — | 1 | 6.17 |
| CHEMBL536759 | — | — | 1 | 5.35 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL538089 | — | Ki | = | 8.27 | nM | 8.08 |
| CHEMBL535857 | — | Ki | = | 9.02 | nM | 8.04 |
| CHEMBL535856 | — | Ki | = | 9.24 | nM | 8.03 |
| CHEMBL535634 | — | Ki | = | 11.8 | nM | 7.93 |
| CHEMBL536305 | — | Ki | = | 12.6 | nM | 7.90 |
| CHEMBL541390 | — | Ki | = | 26.4 | nM | 7.58 |
| CHEMBL282433 | DITOLYLGUANIDINE | Ki | = | 30.8 | nM | 7.51 |
| CHEMBL538091 | — | Ki | = | 117.0 | nM | 6.93 |
| CHEMBL558572 | — | Ki | = | 412.0 | nM | 6.38 |
| CHEMBL555969 | — | Ki | = | 520.0 | nM | 6.28 |
| CHEMBL537696 | — | Ki | = | 600.0 | nM | 6.22 |
| CHEMBL535410 | — | Ki | = | 643.0 | nM | 6.19 |
| CHEMBL535636 | — | Ki | = | 672.0 | nM | 6.17 |
| CHEMBL536759 | — | Ki | = | 4480.0 | nM | 5.35 |