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Compound Detail

CHEMBL535636

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COc1ccc2cccc(CCCN3CCCC(C)(C)C3)c2c1.Cl

Basic Information

ChEMBL ID CHEMBL535636
Phase Preclinical
Structure Type MOL
InChI Key JVDCAJUHSWQIBL-UHFFFAOYSA-N
Parent Compound CHEMBL1188220
Active Moiety CHEMBL1188220
3
Targets
3
Activities
1
Assay Types
0
PK Parameters
3
Publications
0
Known Names

Molecular Properties

311.5
MW (Da)
4.90
ALogP
2
HBA
0
HBD
12.5
PSA (Ų)
0.78
QED
0
Ro5 Violations
5
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C21H30ClNO
MW 347.93
Aromatic Rings 2
Heavy Atoms 23
NP-Likeness -0.29

Activity Summary

Ki 3 meas. best 8.38

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase
CHEMBL5525
Ki 8.38 8.38 4.1 1
Sigma non-opioid intracellular receptor 1
CHEMBL4153
Ki 6.94 6.94 115.0 1
Unchecked
CHEMBL612545
Ki 6.17 6.17 672.0 1

Activity Data Samples

Top measurements by pChEMBL value

Literature References

PubMed DOI Target Context # Activities
17713896 10.1021/jm070373b Unchecked 2
17713896 10.1021/jm070373b Sigma non-opioid intracellular receptor 1 1
17713896 10.1021/jm070373b 3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase 1

Data from ChEMBL 36 via Core Engine