Skip to main content
Free research Free research Free assay review with research home and workspace preview
Quick search ChEMBL 36
Assay Detail

CHEMBL896185

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Displacement of [3H]emopamil from Delta-(8)-Delta-(7) sterol isomerase in guinea pig liver membrane
14
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Cavia porcellus
Tissue Liver
Subcellular Membrane
Confidence 9 — Direct single protein target
Curated By Intermediate

Target

3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase (CHEMBL5525)
Type SINGLE PROTEIN
Organism Cavia porcellus

Publication

Design and evaluation of naphthol- and carbazole-containing fluorescent sigma ligands as potential probes for receptor binding studies.
Ferorelli S, Abate C, Colabufo NA, Niso M, Inglese C, Berardi F, Perrone R.
J Med Chem (2007) 50 : 4648 -4655
PubMed 17713896 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 14 7.46 8.38

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL535636 1 8.38
CHEMBL535856 1 8.35
CHEMBL535857 1 8.15
CHEMBL535410 1 7.89
CHEMBL305187 IFENPRODIL 2.0 1 7.70
CHEMBL541390 1 7.67
CHEMBL538091 1 7.62
CHEMBL558572 1 7.52
CHEMBL538089 1 7.37
CHEMBL535634 1 7.26
CHEMBL536305 1 7.10
CHEMBL555969 1 6.57
CHEMBL536759 1 6.46
CHEMBL537696 1 6.45

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL535636 Ki = 4.12 nM 8.38
CHEMBL535856 Ki = 4.51 nM 8.35
CHEMBL535857 Ki = 7.06 nM 8.15
CHEMBL535410 Ki = 12.8 nM 7.89
CHEMBL305187 IFENPRODIL Ki = 19.8 nM 7.70
CHEMBL541390 Ki = 21.3 nM 7.67
CHEMBL538091 Ki = 24.0 nM 7.62
CHEMBL558572 Ki = 30.0 nM 7.52
CHEMBL538089 Ki = 42.4 nM 7.37
CHEMBL535634 Ki = 55.0 nM 7.26
CHEMBL536305 Ki = 79.9 nM 7.10
CHEMBL555969 Ki = 270.0 nM 6.57
CHEMBL536759 Ki = 345.0 nM 6.46
CHEMBL537696 Ki = 352.0 nM 6.45