Assay Detail
Functional
CHEMBL896194
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Inhibition of P-EGFR expressed in A431 cells
17
Total Activities
17
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | A-431 |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Inhibitors of tumor progression loci-2 (Tpl2) kinase and tumor necrosis factor alpha (TNF-alpha) production: selectivity and in vivo antiinflammatory activity of novel 8-substituted-4-anilino-6-aminoquinoline-3-carbonitriles.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 17 | 6.05 | 7.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL220037 | — | — | 1 | 7.52 |
| CHEMBL397949 | — | — | 1 | 6.81 |
| CHEMBL245212 | — | — | 1 | 6.30 |
| CHEMBL436817 | — | — | 1 | 5.75 |
| CHEMBL241990 | — | — | 1 | 5.68 |
| CHEMBL395573 | — | — | 1 | 5.54 |
| CHEMBL241988 | — | — | 1 | 5.48 |
| CHEMBL242206 | — | — | 1 | 5.30 |
| CHEMBL242426 | — | — | 1 | - |
| CHEMBL242425 | — | — | 1 | - |
| CHEMBL242207 | — | — | 1 | - |
| CHEMBL425834 | — | — | 1 | - |
| CHEMBL230232 | — | — | 1 | - |
| CHEMBL395997 | — | — | 1 | - |
| CHEMBL242208 | — | — | 1 | - |
| CHEMBL241989 | — | — | 1 | - |
| CHEMBL242852 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL220037 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL397949 | — | IC50 | = | 156.0 | nM | 6.81 |
| CHEMBL245212 | — | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL436817 | — | IC50 | = | 1800.0 | nM | 5.75 |
| CHEMBL241990 | — | IC50 | = | 2080.0 | nM | 5.68 |
| CHEMBL395573 | — | IC50 | = | 2900.0 | nM | 5.54 |
| CHEMBL241988 | — | IC50 | = | 3300.0 | nM | 5.48 |
| CHEMBL242206 | — | IC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL242426 | — | IC50 | - | — | - | |
| CHEMBL242425 | — | IC50 | - | — | - | |
| CHEMBL242207 | — | IC50 | - | — | - | |
| CHEMBL425834 | — | IC50 | > | 5000.0 | nM | - |
| CHEMBL230232 | — | IC50 | > | 5000.0 | nM | - |
| CHEMBL395997 | — | IC50 | - | — | - | |
| CHEMBL242208 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL241989 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL242852 | — | IC50 | > | 5000.0 | nM | - |