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Assay Detail

CHEMBL896227

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Functional
Antiviral activity against RSV in HeLaM cells
23
Total Activities
23
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Respiratory syncytial virus
Cell Type HeLaM
Confidence 1 — Organism
Curated By Intermediate

Target

Respiratory syncytial virus (CHEMBL612679)
Type ORGANISM
Organism Respiratory syncytial virus

Publication

Selection of a respiratory syncytial virus fusion inhibitor clinical candidate, part 1: improving the pharmacokinetic profile using the structure-property relationship.
Bonfanti JF, Doublet F, Fortin J, Lacrampe J, Guillemont J, Muller P, Queguiner L, Arnoult E, Gevers T, Janssens P, Szel H, Willebrords R, Timmerman P, Wuyts K, Janssens F, Sommen C, Wigerinck P, Andries K.
J Med Chem (2007) 50 : 4572 -4584
PubMed 17722899 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
EC50 23 7.57 9.60

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL390896 1 9.60
CHEMBL242456 JNJ 2408068 1 9.60
CHEMBL242458 1 9.50
CHEMBL390676 1 9.20
CHEMBL242885 1 8.50
CHEMBL389973 1 8.00
CHEMBL395241 1 7.90
CHEMBL242886 1 7.70
CHEMBL243557 1 7.60
CHEMBL243551 1 7.40
CHEMBL242671 1 7.30
CHEMBL242670 1 7.30
CHEMBL243559 1 6.90
CHEMBL390678 1 6.80
CHEMBL242672 1 6.80
CHEMBL242884 1 6.80
CHEMBL243332 1 6.80
CHEMBL243333 1 6.20
CHEMBL395242 1 6.10
CHEMBL242903 1 5.30
CHEMBL243558 1 -
CHEMBL390677 1 -
CHEMBL243778 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL390896 EC50 = 0.2512 nM 9.60
CHEMBL242456 JNJ 2408068 EC50 = 0.2512 nM 9.60
CHEMBL242458 EC50 = 0.3162 nM 9.50
CHEMBL390676 EC50 = 0.631 nM 9.20
CHEMBL242885 EC50 = 3.162 nM 8.50
CHEMBL389973 EC50 = 10.0 nM 8.00
CHEMBL395241 EC50 = 12.59 nM 7.90
CHEMBL242886 EC50 = 19.95 nM 7.70
CHEMBL243557 EC50 = 25.12 nM 7.60
CHEMBL243551 EC50 = 39.81 nM 7.40
CHEMBL242671 EC50 = 50.12 nM 7.30
CHEMBL242670 EC50 = 50.12 nM 7.30
CHEMBL243559 EC50 = 125.89 nM 6.90
CHEMBL390678 EC50 = 158.49 nM 6.80
CHEMBL242672 EC50 = 158.49 nM 6.80
CHEMBL242884 EC50 = 158.49 nM 6.80
CHEMBL243332 EC50 = 158.49 nM 6.80
CHEMBL243333 EC50 = 630.96 nM 6.20
CHEMBL395242 EC50 = 794.33 nM 6.10
CHEMBL242903 EC50 = 5011.87 nM 5.30
CHEMBL243558 EC50 < 100000.0 nM -
CHEMBL390677 EC50 < 100000.0 nM -
CHEMBL243778 EC50 < 100000.0 nM -